Transcription factor | Regulator of/node point for | Example of downstream effects |
---|---|---|
AP-1 (c-jun/c-fos) | Inflammation | Mmp-12, col1a1, hsp27 |
CREP binding protein (CBP) | Lipid, inflammation, immune response, cell proliferation | Very broadly acting coactivator (can bind to SREBPs) |
C/EBPs | Lipid, inflammation, energy metabolism | Acute phase genes (for SAA, CRP, fibrinogen), hepatic gluconeogenesis and lipid homeostasis, energy metabolism (PEPCK, FAS), TGF-β signaling |
Forkhead transcription factor FOXO1 | Lipid, inflammation/proliferation | Glycolysis, pentose phosphate shunt, and lipogenic and sterol synthetic pathways, LPL (via SHP) |
NF-κB | Inflammation | SAA, CD83, CD86, CCR5, VEGF-C |
PPARα/RXRα | Lipid, inflammation | LPL, ABCA1, macrophage activation, glucose homeostasis |
p53 | Inflammation | HSP27, HSPA4, IFI16, IBP3, RBBP4 |
SMAD3 | Inflammation | Proteases and growth factors (via TGF-β signaling) |
SP-1 | Lipid, inflammation | ABCA1, ICAM-1, cellular matrix genes COL1A1, COL1A2 |
SREBP-1/-2 | Lipid, inflammation | Sterol biosynthesis genes, LDLR, link to C/EBPα |
STAT1/3/5 | Inflammation | Acute phase genes |
YY1 | Inflammation/proliferation | Inflammatory response genes (SAA, vWF, CCR5), cellular matrix genes |