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Figure 12 | Genome Biology

Figure 12

From: Drawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 species

Figure 12

Evolution of the first myosins. The first myosin, called ur-myosin, is expected to consist only of the myosin motor domain. By domain fusion it generated the IQ motif either directly carboxy-terminal to the motor domain (2), or after a gene duplication event (1). After a further gene duplication event, this myosin developed to the class-I myosins as well as the ancestor of most of the other myosin classes after fusion with an SH3 domain (which developed into the amino-terminal SH3-like domain).

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