Identification of novel stem cell markers using gap analysis of gene expression data

Table 3 Gene Ontology terms of marker sets

All	Selected set		High in differentiated		GO	GOID
N1	N2	P2	N3	P3
7,478	4,449		222		Total
976	727	2.85 × 10^-22	81	1.60 × 10^-16	Extracellular region	GO:0005576
169	131	0.001824	17	0.009344	Extracellular matrix	GO:0031012
72	57	>1	12	0.00106	Enzyme inhibitor activity	GO:0004857
2,061	1,390	8.07 × 10^-15	73	>1	Membrane	GO:0016020
865	618	2.44 × 10^-11	25	>1	Signal transducer activity	GO:0004871
587	421	4.00 × 10^-7	15	>1	Receptor activity	GO:0004872
925	637	8.62 × 10^-7	43	>1	Multicellular organismal development	GO:0007275
312	235	6.34 × 10^-6	16	>1	Defense response	GO:0006952
911	614	0.000403	32	>1	Cell communication	GO:0007154
270	201	0.000485	17	>1	Cell adhesion	GO:0007155
436	310	0.000596	18	>1	Organ development	GO:0048513

Column labels are as follows: N1 is the number of genes for a Gene Ontology (GO) category in the unselected marker set; N2 and P2 are the number of genes and P value for the smaller marker set; N3 and P3 are the number of genes and P value for the markers highly expressed in differentiated stem cells; GO is the description of the GO term; and GOID is the GO identifier. P values are computed using the 'All' set of markers as background. GO terms displayed if they represent more than ten genes have at least one associated P value below 0.01 and do not overlap more than 80% with another displayed term.

ISSN: 1474-760X