TY - JOUR AU - Cole, Steve W. AU - Hawkley, Louise C. AU - Arevalo, Jesusa M. AU - Sung, Caroline Y. AU - Rose, Robert M. AU - Cacioppo, John T. PY - 2007 DA - 2007/09/13 TI - Social regulation of gene expression in human leukocytes JO - Genome Biology SP - R189 VL - 8 IS - 9 AB - Social environmental influences on human health are well established in the epidemiology literature, but their functional genomic mechanisms are unclear. The present study analyzed genome-wide transcriptional activity in people who chronically experienced high versus low levels of subjective social isolation (loneliness) to assess alterations in the activity of transcription control pathways that might contribute to increased adverse health outcomes in social isolates. SN - 1474-760X UR - https://doi.org/10.1186/gb-2007-8-9-r189 DO - 10.1186/gb-2007-8-9-r189 ID - Cole2007 ER -