Figure 1

CS-CCC builds on information generated via previously described CCC methods by comparing conserved network interactions across multiple species. CCC methods start by mapping (a) co-conserved proteins pairs to (b) large protein interaction networks. (c) CS-CCC extends this approach by comparing proteins and associated links within such interaction networks to identify the combined set of network interactions as well those interactions that are unique to individual species or common across multiple species. Clusters from three organisms are shown, but the method could examine any genome versus any number of genomes (the unique differences between an organism of choice and each organism are shown in different colors while conserved proteins across species are shown in gray). Common network interactions are shown in blue while unique interactions are shown in either green or red. Org (organism); org0 (organism of choice); P (protein).