TY - JOUR AU - Song, Jun S. AU - Johnson, W. Evan AU - Zhu, Xiaopeng AU - Zhang, Xinmin AU - Li, Wei AU - Manrai, Arjun K. AU - Liu, Jun S. AU - Chen, Runsheng AU - Liu, X. Shirley PY - 2007 DA - 2007/08/29 TI - Model-based analysis of two-color arrays (MA2C) JO - Genome Biology SP - R178 VL - 8 IS - 8 AB - A novel normalization method based on the GC content of probes is developed for two-color tiling arrays. The proposed method, together with robust estimates of the model parameters, is shown to perform superbly on published data sets. A robust algorithm for detecting peak regions is also formulated and shown to perform well compared to other approaches. The tools have been implemented as a stand-alone Java program called MA2C, which can display various plots of statistical analysis for quality control. SN - 1474-760X UR - https://doi.org/10.1186/gb-2007-8-8-r178 DO - 10.1186/gb-2007-8-8-r178 ID - Song2007 ER -