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Table 1 Differentially represented Gene Ontology categories

From: Quantitative genomics of locomotor behavior in Drosophila melanogaster

Category Term Count* Percent P value
Biological process Lipid metabolism 110 6.10 3.10E-09
  Steroid metabolism 41 2.30 9.90E-09
  Cellular lipid metabolism 78 4.30 9.30E-08
  Response to toxin 34 1.90 4.20E-06
  Response to biotic stimulus 94 5.20 7.90E-06
  Transport 309 17.10 9.20E-06
  Defense response 92 5.10 9.60E-06
  Response to chemical stimulus 66 3.60 9.80E-06
  Response to abiotic stimulus 84 4.60 1.20E-05
  Localization 352 19.40 1.40E-05
  Metabolism 799 44.10 1.70E-05
  DNA-dependent DNA replication 22 1.20 3.60E-05
  Establishment of localization 340 18.80 3.70E-05
  Physiological process 1,041 57.50 4.30E-05
  DNA replication 36 2.00 1.60E-04
  Cellular physiological process 958 52.90 2.50E-04
  Secretion 48 2.70 2.80E-04
  Electron transport 74 4.10 3.00E-04
  Response to stress 66 3.60 3.20E-04
  Response to stimulus 191 10.50 3.50E-04
  Secretory pathway 45 2.50 4.30E-04
  Response to endogenous stimulus 31 1.70 7.80E-04
  Response to DNA damage stimulus 28 1.50 8.10E-04
  Sleep 7 0.40 1.00E-03
  Primary metabolism 705 38.90 1.50E-03
  Protein complex assembly 28 1.50 2.60E-03
  Intracellular transport 99 5.50 2.90E-03
  DNA repair 25 1.40 2.90E-03
  Intracellular protein transport 80 4.40 3.90E-03
  Regulation of neurotransmitter levels 26 1.40 4.20E-03
  Cell organization and biogenesis 221 12.20 4.40E-03
  Cellular localization 101 5.60 4.50E-03
  Protein localization 91 5.00 4.60E-03
  Heterophilic cell adhesion 6 0.30 4.70E-03
  Proteolysis 129 7.10 5.20E-03
  Establishment of cellular localization 100 5.50 5.70E-03
  Oxygen and reactive oxygen species metabolism 18 1.00 6.20E-03
  Sulfur metabolism 15 0.80 7.00E-03
  Generation of precursor metabolites and energy 92 5.10 7.50E-03
  Cellular metabolism 711 39.30 7.70E-03
  Neurotransmitter secretion 23 1.30 8.00E-03
  Regulated secretory pathway 23 1.30 8.00E-03
  mRNA export from nucleus 7 0.40 8.40E-03
  Establishment of protein localization 82 4.50 8.90E-03
  Sterol metabolism 10 0.60 9.00E-03
  Macromolecule metabolism 498 27.50 9.70E-03
  Chromosome condensation 9 0.50 1.00E-02
  Nuclear transport 16 0.90 1.00E-02
Molecular function Catalytic activity 639 35.30 3.60E-10
  Monooxygenase activity 38 2.10 1.50E-07
  Oxidoreductase activity 131 7.20 1.40E-06
  Protein binding 693 38.30 2.60E-06
  Transporter activity 208 11.50 1.40E-05
  Electron transporter activity 49 2.70 9.40E-05
  Hydrolase activity 294 16.20 2.70E-04
  Sequence-specific DNA binding 12 0.70 4.40E-04
  Tetrapyrrole binding 16 0.90 1.30E-03
  Heme binding 16 0.90 1.30E-03
  Binding 990 54.70 1.80E-03
  Carbon-carbon lyase activity 14 0.80 2.60E-03
  Electrochemical potential-driven transporter activity 43 2.40 2.80E-03
  Porter activity 43 2.40 2.80E-03
  Calmodulin binding 18 1.00 3.60E-03
  Carbohydrate transporter activity 19 1.00 5.10E-03
  Phosphoric monoester hydrolase activity 36 2.00 6.50E-03
  DNA-directed DNA polymerase activity 10 0.60 6.60E-03
  Sugar porter activity 12 0.70 7.40E-03
  Glutathione transferase activity 11 0.60 8.70E-03
  Sugar transporter activity 13 0.70 1.00E-02
Cellular component Microsome 31 1.70 5.80E-10
  Vesicular fraction 31 1.70 5.80E-10
  Cell fraction 34 1.90 1.20E-09
  Membrane fraction 33 1.80 2.10E-09
  Clathrin coat 9 0.50 3.80E-04
  Replication fork 9 0.50 3.80E-04
  Coated membrane 11 0.60 6.70E-04
  Membrane coat 11 0.60 6.70E-04
  Clathrin vesicle coat 8 0.40 1.10E-03
  Clathrin coated vesicle membrane 8 0.40 1.10E-03
  Golgi apparatus 24 1.30 1.40E-03
  Coated pit 5 0.30 1.50E-03
  Cell 673 37.20 1.60E-03
  Cytoplasmic vesicle membrane 10 0.60 1.70E-03
  Vesicle coat 10 0.60 1.70E-03
  Coated vesicle membrane 10 0.60 1.70E-03
  Cytoplasm 239 13.20 2.90E-03
  Membrane 295 16.30 3.00E-03
  Plasma membrane 83 4.60 3.80E-03
  Alpha DNA polymerase 4 0.20 4.30E-03
  Chromosome 40 2.20 5.00E-03
  1. *Number of genes in the annotation category. Number of genes in the annotation category/total number of significant genes. P value from a modified Fisher exact test for enrichment of genes in an annotation category. The cross-classified factors in the 2 × 2 contingency tables are genes in the annotation category versus not in the annotation category, and significant genes versus all genes on the array.