Figure 3

Satellite replication in ES cells is altered by mutation of chromatin modifiers. (a) Summary of replication timing of repeat sequences in mutant ES cell lines. Top, ideogram of the acrocentric mouse chromosome X, showing the position of minor satellite (Minor sat), major satellite (Major sat) and the X-linked X141 repeat. (b) Examples show replication timing of repeats in wild type (WT, white bars (OS25 for Mll, Eed and Dnmt1; matched wild-type lines for G9a, Suv39 h1/h2 and Dicer)) compared to ES cells mutant for the indicated chromatin modifier (black bars). The mean values and standard error of at least two (two to five) independent experiments are shown.