Table 2 Gene Ontology categories overrepresented among the 165 genes targeted by more than 30 miRNAs
Category | Term | Count | % | P value |
|---|---|---|---|---|
Biological Process 5 | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism | 51 | 30.91 | 5.55E-12 |
Biological Process 4 | Homophilic cell adhesion | 15 | 9.09 | 1.82E-11 |
Biological Process 5 | Transcription | 51 | 30.91 | 1.96E-11 |
Biological Process 4 | Regulation of cellular metabolism | 54 | 32.73 | 9.26E-11 |
Biological Process 3 | Nervous system development | 23 | 13.94 | 1.49E-10 |
Biological Process 3 | Regulation of metabolism | 54 | 32.73 | 1.71E-10 |
Biological Process 3 | Regulation of cellular physiological process | 61 | 36.97 | 2.46E-09 |
Biological Process 3 | Cell-cell adhesion | 15 | 9.09 | 1.10E-08 |
Biological Process 4 | Nucleobase, nucleoside, nucleotide and nucleic acid metabolism | 56 | 33.94 | 5.15E-06 |
Cellular Component 3 | Nucleus | 72 | 43.64 | 1.31E-08 |
Cellular Component 3 | Intracellular membrane-bound organelle | 79 | 47.88 | 2.91E-04 |
Molecular Function 3 | DNA binding | 49 | 29.70 | 1.12E-08 |
Molecular Function 4 | Transcription factor activity | 30 | 18.18 | 8.45E-08 |
Molecular Function 3 | Metal ion binding | 64 | 38.79 | 1.87E-07 |
Molecular Function 3 | Cation binding | 60 | 36.36 | 6.06E-07 |
Molecular Function 5 | Zinc ion binding | 35 | 21.21 | 6.33E-05 |
Molecular Function 4 | Calcium ion binding | 23 | 13.94 | 6.74E-05 |
Molecular Function 4 | Sequence-specific DNA binding | 14 | 8.48 | 4.49E-04 |
Molecular Function 5 | Transcription corepressor activity | 6 | 3.64 | 1.12E-03 |
Molecular Function 3 | Transcription corepressor activity | 6 | 3.64 | 1.69E-03 |
Molecular Function 5 | Calcium-transporting atpase activity | 3 | 1.82 | 6.05E-03 |