| |
ER- (n = 186)
|
ER+ (n = 527)
|
|---|
| |
HR (95% CI)
|
P
|
HR (95% CI)
|
P
|
|---|
|
LN
|
2.28 (1.36-3.85)
|
0.002
|
2.07 (1.47-2.90)
|
<10-4
|
|
LI
|
1.06 (0.66-1.70)
|
0.9
|
1.50 (0.72-3.14)
|
0.58
|
|
IRM
|
2.02 (1.19-3.41)
|
0.009
|
1.25 (0.91-1.71)
|
0.19
|
|
LNa + IRM
|
2.16 (1.28-3.64)
|
0.004
|
2.10 (1.49-2.96)
|
<10-4
|
|
LN + IRMa
|
1.93 (1.14-3.26)
|
0.015
|
1.29 (0.94-1.76)
|
0.11
|
|
LIa + IRM
|
0.86 (0.32-2.28)
|
0.76
|
1.75 (0.41-7.47)
|
0.45
|
|
LI + IRMa
|
2.05 (0.71-5.97)
|
0.19
|
0.57 (0.27-1.19)
|
0.13
|
|
LNa + LI + IRM
|
1.79 (0.70-4.62)
|
0.22
|
1.48 (0.68-3.19)
|
0.32
|
|
LN + LIa + IRM
|
0.84 (0.51-1.38)
|
0.72
|
1.65 (0.38-7.07)
|
0.5
|
|
LN + LI + IRMa
|
2.22 (0.76-6.50)
|
0.15
|
0.57 (0.27-1.20)
|
0.14
|
- The table summarizes the hazard ratio (HR), 95% confidence interval (CI), and log-rank test P values of univariate Cox proportional hazards regression models, with lymph node status (LN = 1/0 for LN +/-), level of lymphocytic infiltration (LI = 1 for low infiltration score, and LI = 0 for high infiltration score) and the classification based on the seven-gene immune response related module (IRM; 2 = down-regulation of module, 1 = upregulation of module) as predictors. aCorresponding values in the multivariate Cox models including LN, LI, and IR module as predictors. The table compares the values for estrogen receptor (ER)- and ER+ breast cancer.
