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Table 3 Classification of ER+ intrinsic subtypes, medullary breast cancer, and BRCA1 tumors into ER- subclasses

From: An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer

  ER+ MBC DBC BRCA1
  Luminal B Luminal A Normal Basal HER2    
n 97 337 32 19 42 22 44 18
n classifiable 37 113 19 17 16 20 33 16
CC+/IR+ 17 2 0 13 11 14 4 13
CC+ 20 2 0 4 1 3 3 2
ECM+ 0 71 16 0 0 1 3 1
SR+ 0 9 0 0 0 0 20 0
IR+ 0 29 3 0 4 2 3 0
  1. Classification of ER+ intrinsic subtypes (527 samples from the integrated cohort NKI2 + EMC + NCH), 22 medullary breast cancers (MBCs) and 44 ductal breast cancers (DBCs) from [38], and 18 BRCA1 mutants from [3] into ER- subclasses, using the nearest centroid criterion with Pearson correlation as distance metric. Only samples with Pearson correlation coefficients larger than 0.25 were deemed classifiable. ER, estrogen receptor.