An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer

Table 3 Classification of ER⁺ intrinsic subtypes, medullary breast cancer, and BRCA1 tumors into ER^- subclasses

	ER⁺					MBC	DBC	BRCA1
	Luminal B	Luminal A	Normal	Basal	HER2
n	97	337	32	19	42	22	44	18
n classifiable	37	113	19	17	16	20	33	16
CC⁺/IR⁺	17	2	0	13	11	14	4	13
CC⁺	20	2	0	4	1	3	3	2
ECM⁺	0	71	16	0	0	1	3	1
SR⁺	0	9	0	0	0	0	20	0
IR⁺	0	29	3	0	4	2	3	0

Classification of ER⁺ intrinsic subtypes (527 samples from the integrated cohort NKI2 + EMC + NCH), 22 medullary breast cancers (MBCs) and 44 ductal breast cancers (DBCs) from [38], and 18 BRCA1 mutants from [3] into ER^- subclasses, using the nearest centroid criterion with Pearson correlation as distance metric. Only samples with Pearson correlation coefficients larger than 0.25 were deemed classifiable. ER, estrogen receptor.

ISSN: 1474-760X