FDR comparison in ER- and ER+ breast cancer. For various significance thresholds (sigth), we plot the fraction of observed genes with P values less than the significance threshold (black) as well as the corresponding fraction of false positives, as estimated using a q value analysis (red). (a) Overall survival for ER+ breast cancer. (b) Overall survival for ER- breast cancer. (c) Time to distant metastasis for ER+ breast cancer. (d) Time to distant metastasis for ER- breast cancer. P values were obtained from the log-rank test using Cox regression models. ER, estrogen receptor; FDR, false discovery rate.