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Table 2 Validation and quantification of alternative splice variants

From: Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns

Splice junction

 

Tissue

Fraction of TG splice

Method

GNAS

Intron 3, exon junction 3-4

Leukocytes

0.14

n = 115

PCGF2

Intron 1

Placenta

0.99

n = 89

CNBP

Intron 3, indel AAG

Leukocytes

0.52

n = 69

  

Brain

0.38

n = 58

  

Placenta

0.33

n = 70

 

Intron 3, indel TTGAAG

Leukocytes

0.01

n = 69

FBXO17

Intron 3

Leukocytes

-

n = 96

  

Liver

-

n = 151

C21orf63

Intron 3

Leukocytes

0.09

n = 110

  

Brain

-

Direct sequencing

BRUNOL4

Intron 6

Lung

-

n = 90

  

Brain

0.19

n = 92

PCID2

Intron 2

Leukocytes

0.02

n = 142

TNNT2

Intron 1

Heart

0.03

n = 91

CACNA1A

Intron 9, indel GAG

Brain

0.85

n = 90

 

Intron 9, indel TTGGAG

Brain

0.03

n = 90

ARS2

Intron 18

Leukocytes

0.55

n = 37

PCBP2

Intron 7

Leukocytes

0.54

n = 47

LOC346653

Intron 1

Testis

0.50

Direct sequencing

  1. In the 'Methods' column, n represents the number of subclones sequenced.