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Table 2 GFCS evaluated from species-specific ProtSemNet

From: Novel metrics for evaluating the functional coherence of protein groups via protein semantic network

KEGG pathway

GFCSe

P

GFCSd

P

Apoptosis (hsa04210)

86

9.35 × e-8

5.36

1.59 × e-8

Glycolysis (hsa00010)

68

1.62 × e-10

7.29

0.84a

Focal adhesion (hsa04510)

174

1.56 × e-14

12.48

7.51 × e-5

JAK-STAT (hsa04630)

147

2.52 × e-27

12.11

1.56 × e-05

ATP synthesis (mmu00190)

33

3.01 × e-08

3.42

1.17 × e-04

Calcium signaling (mmu04020)

102

0.04

9.24

2.91 × e-6

Actin regulation (mmu04810)

122

3.37 × e-5

7.47

6.48 × e-13

Cytokine receptor (mmu04060)

176

1.65 × e-39

15.62

0.99a

Purine metabolism (sce00230)

111

3.69 × e-4

8.33

0.34a

MAPK (sce04010)

78

5.65 × e-8

3.15

5.61 × e-8

Ribosome (sce03010)

113

1.61 × e-26

16.58

0.999a

Oxidative phosphorylation (sce00190)

74

1.6 × e-12

5.42

0.001

  1. GFCS, group functional coherence score; JAK, Janus kinase; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinase; ProtSemNet, protein semantic network; STAT, signal transducer and activator of transcription. aNon-significant P value.