Figure 3

Representative chromosomes from the human and virtual sheep genome browsers. (a) Chromosome overview of HSA17 showing some of the datasets generated during the construction of the virtual sheep genome. The human genome browser overview tracks shown are as follows and are labelled as referred to in the text: unsequenced regions; gaps in the human genome assembly; cytogenetic markers; sheep markers version 4.6; cow-human conserved synteny; chicken-mammal conserved synteny; mammalian conserved synteny; sheep-dog-human conserved syntenic blocks calculated from the mapping of the sheep BACs to the dog and human genomes; consolidated MegaBAC-CGCs (the final set of 1,172 BAC-CGCs generated from the MegaBAC-CGCs) and the sheep-via-dog and sheep-via-cow BAC-CGCs; MegaBAC-CGCs (calculated from the MegaBAC analysis and before the final consolidation); sheep-via-dog BAC-CGCs (built on the dog genome and mapped onto the human genome); sheep-via-cow BAC-CGCs (built on the cow genome and mapped onto the human genome). (b) Chromosome overview of OAR11 showing cMegaBAC-CGC sections color coded to indicate the method and likely robustness of assignment (Table 3). A selection of virtual sheep genome browser overview tracks is shown. Labelling is as above; in addition, the microsatellite tracks are shown. BACs are shown in the tail-head outsize track, tail-tail outsize track, and so on, on the basis of their group in the MegaBAC analysis, not their actual size and BAC-end sequence orientations in the virtual sheep genome. All images are from genome databases displayed using Gbrowse [45]. BAC, bacterial artificial chromosome; CGC, comparative genome contig; HSA, human chromosome; OAR, sheep chromosome.