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Figure 3 | Genome Biology

Figure 3

From: High-throughput analysis of spatio-temporal dynamics in Dictyostelium

Figure 3

Early cell-cell signaling. (a) The wavelet transform was further reduced to a one-dimensional representation by tracing the peak of the averaged wavelet power spectrum as a function of time t. The traced data were then subjected to K-mean clustering. The bottom cluster comes from experimental runs where the normal 5-min optical-density oscillations were not detected. Other clusters are wild type with respect to signaling periodicity but are grouped according to the difference in wave onset. The second cluster from the bottom shows large deviations in the timing and consists mainly of samples with low cell density. (b) The frequency of the optical-density oscillations before termination is narrowly distributed and highly reproducible. (c) The wavelet power spectrum, on the other hand, follows a log-normal distribution. (d) The number of spiral cores in an area of 2.1 cm2 and (e) the time of cessation of the periodic signaling follow a Gaussian distribution (shown as a dashed curve). (f-i) Scatter plots indicate relations between these measures that reflect properties of the self-organizing pattern formation from random initial conditions (see main text for details). Correlation coefficients are (f) -0.20, (g) 0.05, (h) -0.37 and (i) 0.15 respectively. Original data are provided as Additional data files 9-13.

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