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Table 3 Transcription factors with predicted binding motifs over-represented in HK gene promoters

From: Housekeeping genes tend to show reduced upstream sequence conservation

Transcription factor Description Expression breadth
AHR and ARNT Aryl hydrocarbon receptor; it can interact with ARNT (AHR:ARNT heterodimer) INT
ATF family Activating transcription factor HK
CREB family cAMP responsive element binding protein INT
E2F family E2F transcription factor INT and HK
HIF1A Hypoxia inducible factor 1, alpha subunit; as AHR, it can interact with ARNT HK
MYC and MAX Proto-oncogene protein c-myc and MYC associated factor X; they can form MYC:MAX heterodimers INT and HK
NRF1 and NRF2 Nuclear respiratory factor 1 and 2 INT and HK
SP1 SP1 transcription factor HK
USF Upstream transcription factor (USF1 and USF2) INT
  1. HK, housekeeping; INT, intermediate.