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Table 2 Average promoter divergence values (dSM) for HK and non-HK genes classified in different GO classes

From: Housekeeping genes tend to show reduced upstream sequence conservation

   All CpG+ CpG-
GO term Description N dSM (HK) dSM (nonHK) N dSM (HK) dSM (nonHK) N dSM (HK) dSM (nonHK)
Molecular function           
   GO:0000166 Nucleotide binding 464 0.727 0.699 363 0.732 0.698 101 0.684 0.700
   GO:0004872 Receptor activity 259 0.734 0.675 131 0.747 0.656 128 0.655 0.692
   GO:0004871 Signal transducer activity 440 0.689 0.658 246 0.692 0.656 194 0.663 0.661
   GO:0003700 Transcription factor activity 183 0.673 0.602 113 0.657 0.600 70 0.766 0.605
   GO:0043169 Cation binding 485 0.711 0.671 308 0.732 0.670 177 0.582 0.671
Biological process           
   GO:0044249 Cellular biosynthesis 256 0.765 0.735 183 0.781 0.729 73 0.629 0.741
   GO:0045184 Establishment of protein transport 162 0.720 0.737 138 0.723 0.731 24 0.677 0.760
   GO:0007049 Cell cycle 188 0.697 0.706 152 0.703 0.724 36 0.656 0.646
   GO:0019538 Protein metabolism 700 0.748 0.703 523 0.755 0.698 177 0.682 0.713
   GO:0044260 Cellular macromolecule metabolism 761 0.748 0.705 560 0.755 0.700 201 0.686 0.713
   GO:0050874 Organismal physiological process 292 0.795 0.681 109 0.813 0.675 183 0.756 0.685
   GO:0009605 Response to external stimulus 209 0.676 0.711 85 0.758 0.699 124 0.538 0.718
   GO:0007166 Cell surface receptor linker signal transduction 221 0.683 0.626 113 0.659 0.645 108 0.762 0.609
   GO:0048513 Organ development 214 0.677 0.566 103 0.699 0.528 111 0.633 0.598
   GO:0009653 Morphogenesis 262 0.679 0.584 132 0.685 0.549 130 0.664 0.615
   GO:0009607 Response to biotic stimulus 166 0.761 0.723 74 0.783 0.686 92 0.680 0.745
   GO:0007165 Signal transduction 563 0.684 0.656 342 0.687 0.668 221 0.666 0.643
Cellular component           
   GO:0005739 Mitochondrion 171 0.785 0.756 148 0.780 0.770 23 0.869 0.707
   GO:0005737 Cytoplasm 773 0.756 0.719 579 0.759 0.727 194 0.728 0.707
   GO:0005783 Endoplasmic reticulum 153 0.791 0.713 112 0.776 0.712 41 0.881 0.713
   GO:0005576 Extracellular region 219 0.653 0.621 77 0.718 0.591 142 0.523 0.635
   GO:0005886 Plasma membrane 373 0.720 0.661 189 0.735 0.656 184 0.663 0.666
  1. Entries in bold are those that have a significantly different dSM distribution (p < 0.05). The number of genes (N) is indicated for each GO class. Results for CpG+ and CpG- genes are shown.