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Table 1 Sequence divergence versus tissue expression breadth

From: Housekeeping genes tend to show reduced upstream sequence conservation

No. of tissues N (total = 3,893) dSM Kp Ka Ks Ka/Ks
01-10 986 0.688 0.337 0.107 0.733 0.150
   0.735 0.328 0.084 0.673 0.119
   0.221 0.110 0.093 0.299 0.122
11-50 1,889 0.701 0.333 0.079 0.708 0.116
   0.752 0.328 0.058 0.633 0.089
   0.216 0.093 0.073 0.307 0.103
51-55 1,018 0.732 0.328 0.050 0.639 0.079
   0.791 0.323 0.031 0.572 0.054
   0.208 0.079 0.057 0.305 0.085
  p value (K-W test) <10-5 0.226 <10-75 <10-18 <10-62
  1. N, number of genes; dSM, promoter divergence (see text); Kp, promoter substitution rate; Ka, non-synonymous substitution rate; Ks, synonymous substitution rate. Mean (top), median (middle), and standard deviation (bottom) are indicated for each variable. Numbers in bold indicate significant differences at p < 0.001 in each expression group with respect to the rest (two-sample Wilcoxon-Mann-Whitney test). The last row shows the p value of Kruskal-Wallis (K-W) test that evaluates differences between the three tissue expression breadth groups.