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Table 1 Putative decay components in Plasmodium falciparum were identified using known factors from human and yeast

From: Whole-genome analysis of mRNA decay in Plasmodium falciparumreveals a global lengthening of mRNA half-life during the intra-erythrocytic development cycle

Components

Gene

PlasmoDB ID

Description

Deadenylation

Ccr4

PFE0980c†

Catalytic subunit of the Ccr4/Pop2 deadenylase complex

 

Pop2

MAL8P1.104†

Component of the Ccr4/Pop2 deadenylase complex

 

Not1

PF11_0049†

Component of the Ccr4/Not complex

 

Not2

PF11_0297†

Component of the Ccr4/Not complex

 

Not3

?

Component of the Ccr4/Not complex

 

Not4

PFL1705w†

Component of the Ccr4/Not complex

 

Not5

PF10_0062†

Component of the Ccr4/Not complex

 

Caf130

?

Component of the Ccr4/Not complex

 

Caf40

PFE0375w

Component of the Ccr4/Not complex

 

PARN

PF14_0413*†

Major deadenylase in mammals

 

Pab1

PFL1170w

PolyA binding protein

 

Pan2

?

Component of the Pan2/Pan3 deadenylase complex

 

Pan2

?

Component of the Pan2/Pan3 deadenylase complex

Decapping

Dcp1

PF10_0314*†

Component of the Dcp1/Dcp2 decapping complex

 

Dcp2

Pf13_0048†

Catalytic subunit of the Dcp1/Dcp2 decapping complex

 

DcpS/Dcs1

?

Scavenger decapping enzyme

 

Dhh1

PFC0915w

Helicase-roles in deadenylation and decapping

 

Lsm1

PF11_0255†

Involved in decapping

 

Lsm2

PFE1020w

Involved in decapping

 

Lsm3

PF08_0049

Involved in decapping

 

Lsm4

PF11_0524

Involved in decapping

 

Lsm5

PF14_0411

Involved in decapping

 

Lsm6

PF13_0142

Involved in decapping

 

Lsm7

PFL0460w

Involved in decapping

Exosome

Csl4

MAL7P1.104

Exosome subunit

 

Dis3/Rrp44

MAL13P1.289†

Exosome subunit-RNase II domain

 

Mtr3

?

Exosome subunit-RNase PH domain

 

Rrp4

PFD0515w

Exosome subunit-hydrolytic exonuclease

 

Rrp40

MAL13P1.36†

exosome subunit-hydrolytic exonuclease

 

Rrp42

MAL13P1.204†

Exosome subunit-RNase PH domain

 

Rrp43

?

Exosome subunit-RNase PH domain

 

Rrp45

PF13_0340

Exosome subunit-RNase PH domain

 

Rrp46

?

Exosome subunit-RNase PH domain

 

Rrp6

PF14_0473

Exosome subunit found only in the nucleus

 

Ski2

PFI0480w

Helicase associated with the exosome and Ski complex

 

Ski3/Ski5

?

Associated with exosome and Ski complex

 

Ski6/Rrp41

PF14_0256

Exosome subunit-RNase PH domain

 

Ski7

?

Associated with exosome and Ski complex

 

Ski8

?

Associated with exosome and Ski complex

5' to 3' decay

Xrn1

PFI0455w/PF11_0074†

5' to 3' exonuclease-cytoplasmic

 

Rat1

PFI0455w/PF11_0074†

5' to 3' exonuclease-nuclear

  1. Orthologs were identified using a simple reciprocal best BLASTP match between Plasmodium falciparum and Saccharomyces cerevisiae and between P. falciparum and human sequences. Orthologs could not be found for those genes with question marks. *Components identified only when the human sequence was used for the query sequence. †P. falciparum proteins that either are described in PlasmoDB as hypothetical proteins or, in the case of PF10_0314, are assigned a function other than the one relevant here.