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Table 2 Summary of morphine-induced changes in gene expression level in the four inbred strains

From: Morphine effects on striatal transcriptome in mice

Treatment Fold change over control All of the four strains 129P3/J strain C57BL/6J strain DBA/2J strain SWR/J strain
Acute upregulation >1.2a 181 179 106 313 255
  >1.5 38 33 39 81 42
Acute downregulation >1.2 69 44 108 68 67
  >1.5 6 4 25 25 14
Chronic upregulation >1.2 76 90 116 59 63
  >1.5 13 17 38 8 10
Chronic downregulation >1.2 145 83 278 98 141
  >1.5 9 9 61 10 12
  1. The mouse strains evaluated were 129P3/J, C57BL/6J, DBA/2J, and SWR/J. aAnalysis was performed for the group of transcripts significantly changed after morphine treatment. Relative expression levels for 661 probe sets were computed using MBEI perfect match/mismatch (PM/MM) data.