Figure 12
From: Estimation and correction of non-specific binding in a large-scale spike-in experiment
Performance measures for very high intensity MM probesets. (a) Plot of mean log2 fold changes for FC = 2 probesets with q-values below 0.10 for MM and PM very high intensity probesets. Very high intensity probesets have a mean log2 expression value greater than 12 across all 301 methods used to generate expression values. (b) Plot of ratio of mean fold change of TPs (FC = 2) divided by mean fold change of FPs (empty and FC = 1) with q-values below 0.10. (c) Plot of AUC scores for very high intensity probesets that can be aligned to present transcripts based on Cyber-T P values. TPs were FC > 1 probesets and mixed probesets that could be aligned to spiked-in transcripts. All other probesets are true negatives. (d) Plot of true q-values based on the calculated q-values below 0.10. BG, background.