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Table 5 Effects of RNAi and cadmium on C. elegans reproduction

From: Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity

Target gene

CGC gene name

Reproduction rate (minus cadmium)*

Reproduction rate (plus cadmium)*

Diff. of medians

P value†

T10B9.1

cyp-13A4

0.92, 0.92, 0.88, 0.96, 0.87

0.57, 0.59, 0.61, 0.79, 0.72

0.31

0.008

F28D1.3

thn-1

1.04, 1.02, 1.14, 1.03

0.89, 0.86, 0.92, 0.92

0.13

0.029

F35E8.11

cdr-1

1.01, 1.02, 0.94, 0.95, 1.19, 1.04

1.38, 1.21, 0.88, 0.79, 0.80, 0.84

0.15

0.394

Y39B6A.24

 

1.10, 1.03, 1.09

1.01, 1.21, 1.03

0.06

0.700

T26H2.5

 

0.88, 0.99, 0.81

0.74, 0.95, 1.00

-0.07

1.000

K11G9.6

mtl-1

0.85, 1.13, 0.99, 0.90, 1.07

0.97, 1.16, 1.12, 1.08, 1.12

-0.13

0.222

T27F6.2

clec-12

1.10, 0.90, 1.00, 1.03, 0.64, 0.90

1.05, 1.32, 1.42, 0.94, 1.32, 0.83

-0.24

0.180

C17H1.4

 

0.87, 0.89, 1.13

0.91, 1.06, 1.75

-0.15

0.686

C08E3.10

 

0.94, 0.93, 1.03

1.39, 1.24, 1.26

-0.32

0.100

M88.1

ugt-62

0.93, 1.03, 0.99, 1.05, 0.98, 0.89

1.08, 0.94, 1.34, 0.83, 0.95, 0.88

0.04

0.818

Y39E4A.2

ttm-1

0.73, 0.88, 1.05, 0.91, 0.94, 0.83, 1.01, 1.03

0.86, 0.82, 1.12, 0.91, 0.94, 0.93, 0.83, 0.85

0.04

0.721

F42C5.3

 

1.01, 0.94, 1.02, 1.12, 1.05, 0.99

1.06, 1.19, 1.10, 0.94, 0.91, 0.90

0.02

0.818

F53H2.1

 

1.06, 0.94, 1.00, 1.20, 0.95, 0.93

1.27, 1.30, 1.05, 1.05, 1.07, 0.96

-0.08

0.132

F09B9.1

 

0.76, 1.04, 1.06, 0.89, 1.13, 0.96, 1.01

1.04, 0.73, 0.95, 0.72, 0.88, 0.85, 0.92

0.13

0.073

Y46G5A.24

 

1.10, 0.94, 1.12

0.98, 0.87, 0.80

0.23

0.200

  1. *The reproduction rate was calculated by comparing the number of offspring with the targeted gene knocked-down by RNAi to those without RNAi in the same cadmium-treatment group during a two day reproduction period after nematodes reached L4 stage of development. †Wilcoxon Rank-sum tests were applied for significance tests.