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Table 1 Genes whose expression changes following 4 h or 24 h cadmium exposure

From: Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity

Gene name

CGC gene name

4 h exposure

24 h exposure

  

Fold change

P value

Fold change

P value

Up-regulated genes (early response group)

     

   F35E8.11

cdr-1

73.4

1.00E-43

111.4

3.10E-43

   T08G5.10

mtl-2

28.7

1.70E-38

31.7

<1.0E-43

   K11G9.6

mtl-1

17.1

6.28E-40

15.0

4.71E-39

   R04D3.1

cyp-14A4

14.9

5.32E-37

32.4

4.02E-34

   T26H2.5

 

10.1

6.57E-27

15.2

2.88E-38

   Y46G5A.24

 

7.4

1.32E-37

18.3

6.16E-37

   F56A4.5

 

6.5

1.96E-29

11.8

1.32E-32

   T10B9.10

cyp-13A7

6.3

2.57E-26

6.9

4.00E-26

   AC3.7

ugt-1

5.4

4.16E-42

8.2

3.46E-37

   F41B5.2

cyp-33C7

5.3

6.86E-30

6.9

5.18E-42

   T08G5.1

 

4.9

1.20E-27

6.8

4.04E-32

   T16G1.6

 

4.5

1.16E-41

6.1

3.91E-36

   T10B9.1

cyp-13A4

4.3

6.38E-40

7.1

1.12E-35

   F28D1.3

thn-1

4.0

7.88E-34

9.9

1.50E-42

   F53C3.12

 

3.9

1.07E-31

5.7

2.12E-40

   C02A12.1

gst-33

3.8

2.57E-33

7.8

2.15E-33

   Y59E9AR.4

thn-5

3.7

2.50E-35

8.5

4.87E-42

   F28D1.4

thn-3

3.6

2.69E-23

14.3

6.80E-33

   Y39B6A.24

 

3.4

7.06E-31

11.4

4.48E-42

   F28D1.5

thn-2

3.4

3.45E-30

3.7

3.51E-35

   T18D3.3

 

3.3

2.18E-31

4.3

1.45E-35

   T16G1.5

 

3.0

1.65E-30

2.2

1.02E-29

   T10B9.2

cyp-13A5

2.9

3.11E-36

4.4

1.22E-34

   C17H1.3

 

2.7

5.00E-17

4.0

7.58E-25

   Y40B10A.6

 

2.6

2.99E-20

3.8

6.72E-23

   Y40B10A.7

 

2.4

1.41E-20

3.5

1.59E-22

   C27H5.4

 

2.4

1.90E-27

4.1

1.52E-32

   F26F2.3

 

2.4

1.77E-14

2.7

1.66E-19

   F49F1.6

 

2.4

6.64E-33

3.4

2.19E-38

   F45D11.4

 

2.3

1.52E-22

3.3

6.57E-31

   F49F1.7

 

2.2

2.93E-20

2.8

6.66E-24

   E02A10.2

grl-23

2.1

2.47E-07

2.6

3.93E-19

   K04A8.5

 

2.1

1.04E-25

3.0

2.50E-23

   W01A11.1

 

2.1

2.01E-28

2.3

1.28E-31

   F45D11.14

 

2.1

9.71E-09

2.6

2.43E-14

   F37B1.8

gst-19

2.0

8.18E-24

2.7

2.40E-27

   C31A11.5

 

2.0

7.33E-24

1.7

3.35E-18

Up-regulated genes (late response group)

     

   F08F8.5

   

7.1

1.06E-28

   B0507.8

 

1.8

4.14E-09

5.6

2.51E-32

   C08E3.6

   

5.2

2.02E-27

   F35E8.8

gst-38

1.6

3.05E-20

5.0

1.41E-28

   C31B8.4

 

1.8

5.34E-09

4.3

2.57E-37

   C17H1.8

   

4.0

5.83E-19

   T01C3.4

 

1.6

3.18E-07

3.7

3.88E-32

   F15E11.12

   

3.4

1.88E-10

   W08A12.4

 

1.6

2.66E-12

3.3

2.54E-27

   F48C1.9

   

3.3

2.97E-14

   R05D8.9

 

1.8

9.43E-18

3.2

4.16E-25

   ZC196.6

   

3.0

1.18E-26

   C08E3.10

 

1.6

2.44E-08

3.0

1.58E-30

   Y73C8C.2

 

1.8

1.45E-22

3.0

3.27E-28

   T08E11.1

   

2.9

5.78E-24

   C54D10.8

   

2.9

3.96E-24

   C17H1.4

   

2.9

5.74E-21

   Y39G8B.7

   

2.8

1.55E-26

   C45G7.3

   

2.8

7.31E-23

   F15B9.6

 

1.5

2.29E-17

2.7

4.03E-33

   ZK742.3

 

1.5

9.27E-14

2.7

1.04E-24

   C17H1.9

   

2.7

8.10E-18

   T07D10.4

clec-15

1.7

6.03E-10

2.6

1.51E-22

   C08E3.1

   

2.4

1.12E-19

   F37B1.1

gst-24

  

2.4

1.02E-18

   T10B9.3

cyp-13A6

1.9

2.08E-25

2.4

5.68E-25

   C47A10.1

pgp-9

1.8

1.09E-20

2.3

3.32E-21

   F42C5.3

 

1.6

1.37E-11

2.3

3.76E-20

   B0024.4

   

2.3

9.01E-17

   B0507.10

   

2.3

2.11E-23

   Y105C5A.12

   

2.3

1.06E-19

   T27E4.2

hsp-16.11

  

2.3

9.06E-30

   ZK643.8

grl-25

1.8

7.23E-07

2.2

2.62E-19

   F15E6.8

   

2.2

8.03E-23

   F13H6.3

 

1.7

3.31E-25

2.2

6.26E-31

   K02E2.7

   

2.2

1.25E-22

   F57B9.3

   

2.2

1.18E-19

   Y19D10B.7

   

2.2

2.44E-13

   F49H6.5

 

1.5

1.18E-09

2.2

1.19E-16

   C29F7.1

 

1.9

2.15E-24

2.2

3.55E-30

   F44E7.5

 

1.5

6.49E-21

2.2

3.59E-29

   M88.1

ugt-62

1.6

1.06E-23

2.2

2.78E-34

   F53H2.1

   

2.2

2.47E-23

   B0284.2

   

2.1

5.41E-26

   C54D10.7

   

2.1

2.83E-21

   F56C3.9

 

1.5

3.21E-13

2.1

4.20E-23

   T27F6.2

clec-12

  

2.1

1.45E-18

   D2023.7

col-158

1.8

6.26E-07

2.1

6.44E-15

   C29F7.2

   

2.1

1.41E-30

   T12D8.5

   

2.1

5.12E-22

   F41B5.3

cyp-33C5

1.6

8.21E-20

2.1

1.21E-24

   F15A4.8

   

2.0

2.08E-22

   T28D9.3

 

1.7

3.40E-24

2.0

7.68E-30

   F09B9.1

 

1.7

8.66E-20

2.0

1.63E-32

   Y75B8A.28

   

2.0

3.06E-20

   F15E11.1

   

2.0

3.41E-11

   B0284.4

   

2.0

4.57E-13

   F47H4.10

skr-5

  

2.0

2.15E-28

   K09D9.1

   

2.0

3.55E-22

Down-regulated genes

     

   ZK816.5

dhs-26

1.5

1.16E-10

2.3

3.77E-11

   F58B3.3

lys-6

  

2.4

1.35E-17

   F58B3.1

lys-4

  

2.3

3.80E-18

   F58B3.2

lys-5

  

2.1

3.93E-18

   Y48E1B.8

   

2.0

1.01E-15

   Y39G10AR.6

ugt-31

  

2.0

5.16E-18

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Genome Biology

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