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Table 2 The Pfam domains having many combination partners in deuterostome-specific combinations

From: Evolutionary history and functional implications of protein domains and their combinations in eukaryotes

Pfam ID

Number of partners

Group specificity

Definition

VWA

14

Com

von Willebrand factor type A domain

WD40

13

Euk

WD domain, G-beta repeat

MAM

12

Euk

MAM domain

SAM_2

11

Euk

SAM domain (sterile alpha motif)

Lectin_C

11

Euk

Lectin C-type domain

Kunitz_BPTI

11

Ani

Kunitz/Bovine pancreatic trypsin inhibitor domain

Collagen

11

Euk

Collagen triple helix repeat (20 copies)

WW

10

Euk

WW domain

TIL

10

Ani

Trypsin Inhibitor like cysteine rich domain

IQ

10

Euk

IQ calmodulin-binding motif

Trypsin

09

Com

Trypsin

GPS

08

Ani

Latrophilin/CL-1-like GPS domain

GCC2_GCC3

08

Euk

GCC2 and GCC3

Death

08

Ani

Death domain

CH

08

Euk

Calponin homology (CH) domain

zf-RanBP

07

Euk

Zn-finger in Ran binding protein and others

fn2

07

Deu

Fibronectin type II domain

Xlink

07

Deu

Extracellular link domain

F5_F8_type_C

07

Euk

F5/8 type C domain

zf-CCCH

06

Euk

Zinc finger C-x8-C-x5-C-x3-H type (and similar)

Kringle

06

Euk

Kringle domain

Kazal_2

06

Euk

Kazal-type serine protease inhibitor domain

Kazal_1

06

Euk

Kazal-type serine protease inhibitor domain

  1. Shown are hub domains preferentially found in deuterostome-specific combinations. We defined hub domains that are preferentially found in deuterostome-specific combinations as those found in deuterostome-specific combinations more than twice as frequently as in animal-specific combinations. Regarding the group specificity of the domains, the terms 'Euk', 'Ani', and 'Deu' refer to eukaryote, animal, and deuterostome, respectively. 'Com' indicates that the domain is shared by prokaryotes and eukaryotes.