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Table 2 The Pfam domains having many combination partners in deuterostome-specific combinations

From: Evolutionary history and functional implications of protein domains and their combinations in eukaryotes

Pfam ID Number of partners Group specificity Definition
VWA 14 Com von Willebrand factor type A domain
WD40 13 Euk WD domain, G-beta repeat
MAM 12 Euk MAM domain
SAM_2 11 Euk SAM domain (sterile alpha motif)
Lectin_C 11 Euk Lectin C-type domain
Kunitz_BPTI 11 Ani Kunitz/Bovine pancreatic trypsin inhibitor domain
Collagen 11 Euk Collagen triple helix repeat (20 copies)
WW 10 Euk WW domain
TIL 10 Ani Trypsin Inhibitor like cysteine rich domain
IQ 10 Euk IQ calmodulin-binding motif
Trypsin 09 Com Trypsin
GPS 08 Ani Latrophilin/CL-1-like GPS domain
GCC2_GCC3 08 Euk GCC2 and GCC3
Death 08 Ani Death domain
CH 08 Euk Calponin homology (CH) domain
zf-RanBP 07 Euk Zn-finger in Ran binding protein and others
fn2 07 Deu Fibronectin type II domain
Xlink 07 Deu Extracellular link domain
F5_F8_type_C 07 Euk F5/8 type C domain
zf-CCCH 06 Euk Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Kringle 06 Euk Kringle domain
Kazal_2 06 Euk Kazal-type serine protease inhibitor domain
Kazal_1 06 Euk Kazal-type serine protease inhibitor domain
  1. Shown are hub domains preferentially found in deuterostome-specific combinations. We defined hub domains that are preferentially found in deuterostome-specific combinations as those found in deuterostome-specific combinations more than twice as frequently as in animal-specific combinations. Regarding the group specificity of the domains, the terms 'Euk', 'Ani', and 'Deu' refer to eukaryote, animal, and deuterostome, respectively. 'Com' indicates that the domain is shared by prokaryotes and eukaryotes.