Skip to main content

Table 1 The Pfam domains having many combination partners in animal-specific combinations

From: Evolutionary history and functional implications of protein domains and their combinations in eukaryotes

Pfam ID

Number of partners

Group specificity

Definition

Pkinase

37

Com

Protein kinase domain

SH2

19

Euk

SH2 domain

Laminin_EGF

18

Euk

Laminin EGF-like (domains III and V)

C1_1

17

Euk

Phorbol esters/diacylglycerol binding domain (C1 domain)

RA

12

Euk

Ras association (RalGDS/AF-6) domain

Spectrin

11

Euk

Spectrin repeat

PSI

11

Euk

Plexin repeat

C1_3

10

Euk

C1-like domain

PID

09

Ani

Phosphotyrosine interaction domain (PTB/PID)

Homeobox

09

Euk

Homeobox domain

zf-B_box

08

Euk

B-box zinc finger

LRRNT

08

Ani

Leucine rich repeat amino-terminal domain

zf-MYND

07

Euk

MYND finger

RasGEF

07

Euk

RasGEF domain

DEAD

07

Com

DEAD/DEAH box helicase

cNMP_binding

06

Com

Cyclic nucleotide-binding domain

Y_phosphatase

06

Euk

Protein-tyrosine phosphatase

WAP

06

Ani

WAP-type (whey acidic protein) 'four-disulfide core'

UBA

06

Com

UBA/TS-N domain

ResIII

06

Com

Type III restriction enzyme, res subunit

PWWP

06

Euk

PWWP domain

MIB_HERC2

06

Euk

Mib_herc2

LRRCT

06

Ani

Leucine rich repeat carboxyl-terminal domain

LIM

06

Euk

LIM domain

KH_1

06

Com

KH domain

HECT

06

Euk

HECT-domain (ubiquitin-transferase)

DUF1136

06

Ani

Repeat of unknown function (DUF1136)

Band_41

06

Euk

FERM domain (Band 4.1 family)

  1. Shown are hub domains preferentially found in animal-specific combinations. We defined hub domains that are preferentially found in animal-specific combinations as those found in animal-specific combinations more than twice as frequently as in deuterostome-specific combinations. Regarding the group specificity of the domains, the terms 'Euk', 'Ani', and 'Deu' refer to eukaryote, animal, and deuterostome, respectively. 'Com' indicates that the domain is shared by prokaryotes and eukaryotes.