Figure 7

Inhibition of the histone deacetylase activity of Rpd3p results in base composition-dependent gene activation. The dataset describing changes in gene expression upon TSA treatment was obtained from Bernstein et al. [41]. Genes were divided into six groups dependent upon their base composition (as in Figure 1b) and per group the average change in gene expression upon TSA treatment was determined. Error bars are standard error of the mean. Cells were treated for (a) 15 minutes, (b) 30 minutes and (c) 60 minutes with TSA. (d) Average change in gene expression levels in hda1Δ cells for each of the six groups of genes with increasing GC content. Expression data are from Bernstein et al. [41].