Figure 7

Proposed model for induction of the OxyR regulon in O. anthropi. Oxidized oxyR regulates expression of the OxyR regulon in response to oxidative and nitrosative stress, inducing trxC, grxA, gorA and other OxyR regulon genes. ahpC, alkyl hydroperodide reductase I; fhuF, ferric reductase; fur, ferric uptake repressor; GSSH/GSH, oxidized/reduced glutathione; GorA, glutathione reductase; GrxA, glutaredoxin A; katG, catalase (hydroperoxidase I); OMP agn43, outer membrane protein; oxyS, regulatory RNA; RNO, reactive nitrogen species; ROS, reactive oxygen species; TP, thiol peroxidase; TR, thioredoxin 2. (Adapted (with kind permission of Springer Science and Business Media) from Figure 2a [70].)