Figure 2

Phenotypes of the four recessive mutations that were mapped. The b1127 and b1128 mutations cause premature ossification of craniofacial chondral bones and were isolated in the TU background. The b1182 mutation diminishes the differentiation of cartilage and bone in specific elements of the neurocranium and pharyngeal arches, and was isolated in TU. The b1166 mutation causes a shortened body axis, abnormal somite morphology, and clefting of the anterior neurocranium, and was isolated in AB. Cartilage is stained with Alcian blue, and bone with Alizarin red. wt, wild type.