Figure 3

Tissue expression of positive and negative NFκB modulators. Gene-expression data for 79 human tissues using the human Affymetrix U133A array was obtained from Symatlas [23]. The mean expression level and a 99% confidence interval for each gene were then calculated across all 79 human tissues. Using the lower 99% confidence limit as a cutoff, modulators that fell below the cutoff were considered absent in that tissue while those that were expressed above the cutoff were considered present. The black bars represent the number of positive modulators present in a given tissue out of 131 that were contained on the microarray. The light-gray bars represent the number of negative modulators present in a given tissue out of 80 that were contained on the microarray. The number of positive and negative modulators significantly expressed in each tissue was significantly correlated (r = 0.944, p < 0.001).