Table 1 Modular division and FCCRs connecting functional modules for the studied allosteric proteins
| Protein (ID) | Functional sites | Modules | Linking FCCRs |
|---|---|---|---|
| Hemoglobin (1bz0 A) ['15,48,49] | Hem BS | 1,2 | 65(1)(1-2) |
| AB interface | 1 | 66(1)(1-2) | |
| 98(2)(2-1) | |||
| 128(1)(1-2) | |||
| Glycogen phosphorylase (1e1y A) ['50-53] | Cat site | 5 | 84(2)(2-3-4) |
| AMP BS | 1 | 93(1)(1-2-5) | |
| 280 loop* | 2 | 138(2)(2-1-4) | |
| Glycogen BS | 2 | 161(2)(2-1) | |
| Tower helix* | 2 | 490(1)(1-2-5) | |
| 608(5)(5-2) | |||
| 648(5)(5-2-4) | |||
| Retinoic acid receptor RXR-alpha (1g5y A) | Cat ligand BS | 5 | 305(1)(1-5) |
| [54-56] | AF2 helix* | 4 | 309(5)(5-3-1) |
| Coactivator BS | 1,4 | 310(5)(5-1) | |
| AB interface | 5 | 315(5)(5-1) | |
| 371(1)(1-5) | |||
| Catabolite gene activator protein (1g6n A) | DNA BS | 3 | 63(2)(2-3) |
| [57-61] | cAMP BS | 2,1 | 64(2)(2-1-4) |
| 65(2)(2-1-3) | |||
| 69(1)(1-2-4) | |||
| Glutamate dehydrogenase (1hwz A) [62-64] | Cat site | 2 | 110(2) (2-1) |
| NAPH BS | DomA2 in 2 and DomA3 in 5,1 | 173(2) (2-5) | |
| GTP BS | 5 | 211(2) (2-5-1) | |
| Glutamate BS | DomA2 in 2 and DomA3 in 2 | 252(5) (5-1) | |
| Antenna* | 7 | 347(1) (1-5) | |
| Rhodopsine (1l9h A) [65-69] |
Retinal BS G protein BS |
1 2 | 301(1)(1-3-2) |
| Pyruvate kinase (1liu A) [70,71] | Cat site | DomA2 in 5 and DomA3 in 7 | 163(7)(7-4) |
| FBP BS | 3 | 337(6)(6-2-7) | |
| PEP BS | 6,4 | 342(7)(7-6) | |
| 361(6)(6-2-3) | |||
| 482(3)(3-6-2) | |||
| 488(3)(3-6-2) | |||
| Phosphofructokinase (1pfk A) [72-74] | Cat site | DomA1 in 2 and DomA2 in 3 | 126(2)(2-3) |
| FBP BS | DomA1 in 2 and DomA2 in 3 | 139(2)(2-3) | |
| MgADP BS | 2,1 | 169(3)(3-2) | |
| Tyrosine phosphatase 1B (1pty) [28] | Cat site | 2 | 81(2)(2-1) |
| Phosphotyrosine BS | 2,1 | 109(2)(2-1) | |
| Inhibitor BS | 1 | 194(1)(1-2) | |
| 199(1)(1-2) | |||
| 254(1)(1-2) | |||
| 257(2)(2-1) | |||
| Beta-trypsin (2ptc E) ['15,74,76-78] | Cat site | DomA2 in 3 and DomA1 in 3 | 29(3)(3-1) |
| S1 site* | 2,1 | 30(3)(3-1) | |
| Loop1* | 2 | 138(1)(1-2-3) | |
| Loop2* | 2 | 141(1)(1-3) | |
| Loop3* | 2 | 189(2)(2-1) | |
| 194(1)(1-3-2) | |||
| 212(3)(3-2) | |||
| 213(3)(3-1-2) | |||
| 228(2)(2-1-3) | |||
| G-protein s-alpha (1azs C) [19,26,29] | Cat site | DomC1 in 1,4 and DomC2 in 1 | 50(1)(1-4-3) |
| GSP BS | DomC1 in 1 and Dom C2 in 4 | 58(1)(1-4) | |
|
Adenylyl cyclase BS* -Binding only* |
DomC2 in 4,1 and DomC1 in 1 2 |
173(4)(4-1-5) 201(4)(4-1-3) | |
| -Binding and transmission* | DomC2 in 4,1 and DomC1 in 1 | ||
| G-protein beta-gamma (1tbg A) [19,79] | PLC-beta2 BS* | 4 | 61(4)(4-3-2) |
| -Binding only* | 3,2,4 | 63(4)(4-3-2) | |
| -Binding and transmission* | 4 | 105(4)(4-3) | |
| 150(3)(3-4) | |||
| 151(3)(3-4) | |||
| 190(3)(3-2) | |||
| 192(3)(3-2) | |||
| 234(2)(2-3) | |||
| 258(2)(2-1-3) | |||
| 289(2)(2-4) | |||
| 318(2)(2-4) | |||
| 320(2)(2-4) | |||
| Cytochrome P450eryF (1eup A) [32] | Hem BS | 2,6 | 102(6)(6-2-4) |
| Andro1 BS | 6 | 238(6)(6-3) | |
| Andro2 BS | 3 | 349(2)(2-5-6) |