Figure 5

Modular division of the Cytochromes binding sites. (a) Modular division of the Cytochrome P450eryF (PDB ID 1eup) binding site. Two androstenedione molecules (Andro1 and Andro2 colored in blue and purple, respectively) are bound to the protein. The binding site (in spacefill) for the androstenedione is divided into two modules (highlighted in red and yellow) corresponding to the binding area for each of these two molecules. Modular regions not involved in the binding site are depicted in green. (b) Modular division of the Cytochrome P450cam (PDB ID 1noo) binding site. Two camphor molecules (camphor and 5-exo-OH camphor) can bind to the protein. The binding site (in spacefill) for the camphor is highlighted in yellow and orange. The binding site (in spacefill) for the 5-exo-OH camphor is highlighted in red and orange. Residues in orange are the ones that can bind both camphor and hydroxycamphor. Catalytic residues (in spacefill) are highlighted in light blue and purple. The ones in purple can also bind hydroxycamphor. The residues forming each of the four modular regions (and not involved in any of the functions previously described) are depicted in magenta, blue, green and brown.