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Table 3 Comparison of theoretical gene essentiality predictions with results of TraSH experiment in vitro

From: GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosismetabolism

  TraSH threshold of 0.2 TraSH threshold of 0.1 TraSH threshold of 0.1, altered energetic parameters
True positive 154 115 114
False positive 71 110 110
True negative 385 432 432
False negative 95 48 49
Sensitivity 62% 71% 70%
Specificity 84% 80% 80%
Correct predictions 76% 78% 77%
P a < 2.2 × 10-16 < 2.2 × 10-16 < 2.2 × 10-16
  1. aFisher exact test. TraSH, transposon site hybridization.