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Table 4 Human-mouse TFBS conservation dependency on transcription factor identity

From: Regulatory conservation of protein coding and microRNA genes in vertebrates: lessons from the opossum genome

Factor

Motif

Human versus mouse

 

IC

Length

Detectable

% conserved

p value

Over/under

HMG

8.43

9

7

100.00%

0.1029

 

CREB

11.52

8

17

94.12%

0.0257

Over

c-Myb

14.15

11

11

90.91%

0.1186

 

NF-AT1

N/A

N/A

10

90.00%

0.1494

 

IPF1

N/A

N/A

9

88.89%

0.1862

 

p50

15.63

11

8

87.50%

0.2292

 

NF-κB

13.34

10

14

85.71%

0.1425

 

AhR

8.62

6

7

85.71%

0.2775

 

GR

7.06

6

7

85.71%

0.2775

 

E2F-1

10.17

8

12

83.33%

0.1982

 

AP-1

9.44

7

34

82.35%

0.0686

 

HIF-1

11.00

11

11

81.82%

0.2286

 

MITF

N/A

N/A

11

81.82%

0.2286

 

ATF-2

N/A

N/A

9

77.78%

0.2864

 

USF1

10.37

6

9

77.78%

0.2864

 

C/EBPα

11.12

9

22

77.27%

0.1745

 

p53

25.74

18

22

72.73%

0.1897

 

E2F

13.84

8

11

72.73%

0.2631

 

c-Ets-1

N/A

N/A

7

71.43%

0.3193

 

HNF-1α

N/A

N/A

7

71.43%

0.3193

 

Egr-1

13.12

9

12

66.67%

0.2184

 

POU1F1a

7.57

5

12

66.67%

0.2184

 

Sp1

9.22

8

115

66.09%

0.0250

Under

HNF-1α-A

13.66

10

11

63.64%

0.2010

 

GATA-1

5.57

4

14

57.14%

0.1007

 

TCF-4

12.54

7

7

57.14%

0.2032

 

EBF

21.10

15

8

50.00%

0.1120

 

AP-2αA

N/A

N/A

23

47.83%

0.0073

Under

ER-α

N/A

N/A

11

45.45%

0.0405

Under

Crx

11.60

10

7

42.86%

0.0772

 

Gfi1

7.60

4

17

35.29%

0.0012

Under*

AR

N/A

N/A

7

14.29%

0.0022

Under

  1. Factors with more than seven sites detectable between the two species are shown. The p values given pertain to the observed percentage of conserved sites, and were determined using the Fisher's exact test. Over/under, specifies over-conservation or under-conservation of the sites of the corresponding transcription factor (by Fisher's exact test) at the 5% significance level; *Significant under-representation after p value correction (using Bonferroni). Detectable, total number of human transcription factor binding sites located in promoters of mouse orthologous genes; % conserved, percentage of detectable sites that are in conserved regions; IC, information content (total); Length, length of the motif; N/A, there is no available position-specific score matrix model for this transcription factor; TFBS, transcription factor binding site.