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Figure 2 | Genome Biology

Figure 2

From: Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma

Figure 2

Hierarchical clustering analysis of differentially expressed genes in UM-SCC cells. A total of 1,011 differentially expressed genes was extracted from 24,000 cDNA microarray database, based on twofold and greater difference among human normal kerintinocytes (HKCs), UM-SCC cells with wild-type p53-like expression pattern, mutant p53 or wild-type + mutant p53 status (t-test score at P < 0.05, two-tailed). The hierarchical clustering tree was generated using Java Treeview [107]. Four HKCs were grouped on the left, and five UM-SCC cell lines with wild-type p53-like expression pattern were grouped together in the middle, and five UM-SCC cell lines with mutant p53 were grouped to the right, respectively. Over-expressed genes are indicated by red and under-expressed genes by green; and the expression level is proportional to the brightness of the color (see color bar). (a) Entire hierarchical clustering tree included three upregulated clusters (A, B and C [including subclusters C1 to C3]) and three downregulated clusters (D, E and F). (b) Cluster A consisted of 34 genes. (c) Cluster B consisted of 37 genes. mt, mutant; wt, wild-type.

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