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Table 1 Summary of mouse mammary tumor models

From: Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

Tumor model No. of tumors Specificity of lesions Experimental oncogenic lesion(s) Strain Reference
TgWAP-Myc 13 WAP* cMyc overexpression FVB [60]
TgWAP-Int3 7 WAP Notch4 overexpression FVB [61]
TgWAP-T 121 5 WAP pRb, p107, p130 inactivation B6D2 [37]
TgWAP-T 121 2 WAP pRb, p107, p130 inactivation BALB/cJ [37]
TgWAP-Tag 5 WAP SV40 L-T (pRb, p107, p130, p53, p300 inactivation, others); SV40 s-t C57Bl/6 [62]
TgC3(1)-Tag 8 C3(1) SV40 L-T (pRb, p107, p130, p53, p300 inactivation, others); SV40 s-t FVB [63]
TgMMTV-Neu 10 MMTV Unactivated rat Her2 overexpression FVB [64]
TgMMTV-Wnt1 11 MMTV Wnt 1 overexpression FVB [65]
TgMMTV-PyMT 7 MMTV Py-MT (activation of Src, PI-3' kinase, and Shc) FVB [66]
TgMMTV-Cre;Brca1Co/Co;p53+/- 10 MMTV Brca1 truncation mutant; p53 heterozygous null C57Bl/6 [67]
p53-/-transplanted 5 None p53 inactivation BALB/cJ [68]
Medroxyprogesterone-DMBA-induced 11 None Random DMBA-induced FVB [69]
p53+/-irradiated 7 None p53 heterozygous null, random IR induced BALB/cJ [70]
Brca1+/-;p53+/-irradiated 7 None Brca1 and p53 heterozygous null, random IR induced BALB/cJ [1]
  1. *WAP, whey acidic protein promoter, commonly restricted to lactating mammary gland luminal cells. C3(1), 5' flanking region of the C3(1) component of the rat prostate steroid binding protein, expressed in mammary ductal cells. MMTV, mouse mammary tumor virus promoter, often expressed in virgin mammary gland epithelium, induced with lactation; often expressed at ectopic sites (for example, lymphoid cells, salivary gland, others).