Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

Table 1 Summary of mouse mammary tumor models

Tumor model	No. of tumors	Specificity of lesions	Experimental oncogenic lesion(s)	Strain	Reference
TgWAP-Myc	13	WAP*	cMyc overexpression	FVB	[60]
TgWAP-Int3	7	WAP	Notch4 overexpression	FVB	[61]
TgWAP-T₁₂₁	5	WAP	pRb, p107, p130 inactivation	B6D2	[37]
TgWAP-T₁₂₁	2	WAP	pRb, p107, p130 inactivation	BALB/cJ	[37]
TgWAP-Tag	5	WAP	SV40 L-T (pRb, p107, p130, p53, p300 inactivation, others); SV40 s-t	C57Bl/6	[62]
TgC3(1)-Tag	8	C3(1)^†	SV40 L-T (pRb, p107, p130, p53, p300 inactivation, others); SV40 s-t	FVB	[63]
TgMMTV-Neu	10	MMTV^‡	Unactivated rat Her2 overexpression	FVB	[64]
TgMMTV-Wnt1	11	MMTV	Wnt 1 overexpression	FVB	[65]
TgMMTV-PyMT	7	MMTV	Py-MT (activation of Src, PI-3' kinase, and Shc)	FVB	[66]
TgMMTV-Cre;Brca1^Co/Co;p53^+/-	10	MMTV	Brca1 truncation mutant; p53 heterozygous null	C57Bl/6	[67]
p53^-/-transplanted	5	None	p53 inactivation	BALB/cJ	[68]
Medroxyprogesterone-DMBA-induced	11	None	Random DMBA-induced	FVB	[69]
p53^+/-irradiated	7	None	p53 heterozygous null, random IR induced	BALB/cJ	[70]
Brca1^+/-;p53^+/-irradiated	7	None	Brca1 and p53 heterozygous null, random IR induced	BALB/cJ	[1]

*WAP, whey acidic protein promoter, commonly restricted to lactating mammary gland luminal cells. ^†C3(1), 5' flanking region of the C3(1) component of the rat prostate steroid binding protein, expressed in mammary ductal cells. ^‡MMTV, mouse mammary tumor virus promoter, often expressed in virgin mammary gland epithelium, induced with lactation; often expressed at ectopic sites (for example, lymphoid cells, salivary gland, others).

ISSN: 1474-760X