Figure 1

Simulation model used for artificially recreating gene categories with known expression pattern deviations. (a) Density distribution for the reference population (dashed black line), the modulated genes (dotted black line), and the resulting mixture (solid blue line). (b) Corresponding cumulative distributions. The parameter values used in this example were π = 0.2, μ = 1.0, and σ = 1.0, modeling a low-proportion admixture of moderately overexpressed genes.