Table 1 Gene classes induced and repressed upon changes in S. pombe copper or iron status

Low copper (100 mmol/l BCS)

Metal ion transport

5

Oxidoreductases and dehydrogenases

3

Peroxisomal proteins

2

Flavoproteins

2

Other transport

1

Antioxidants

2

Others

3

Low iron (300 mmol/l FZ)

Metal ion transport

8

Localized to the mitochondrion

6

Other transport

2

Transporters

3

Peptide biosynthesis

2

Metal metabolism

2

Iron-Sulfur cluster assembly

1

Iron/sulfur cluster proteins

2

Others/Unknown

19

Thiamine biosynthesis

2

Others/unknown

9

High copper (2 mmol/l CuSO₄)

Protein folding/chaperone

12

Transporters

7

Antioxidants

6

Amino acid metabolism and transport

4

Sulphur amino acid biosynthesis

6

Ribosomal proteins

2

Carbohydrate metabolism

4

Others/unknown

11

Stress response

4

Iron uptake

3

Signaling and transcription regulation

2

Lipid biosynthesis

2

Peptide biosynthesis

2

Other/unknown

28