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Table 1 Gene classes induced and repressed upon changes in S. pombe copper or iron status

From: Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study

Condition Induced Repressed
  Classification Gene number Classification Gene number
Low copper (100 mmol/l BCS) Metal ion transport 5 Oxidoreductases and dehydrogenases 3
  Peroxisomal proteins 2 Flavoproteins 2
  Other transport 1 Antioxidants 2
  Others 3   
Low iron (300 mmol/l FZ) Metal ion transport 8 Localized to the mitochondrion 6
  Other transport 2 Transporters 3
  Peptide biosynthesis 2 Metal metabolism 2
  Iron-Sulfur cluster assembly 1 Iron/sulfur cluster proteins 2
  Others/Unknown 19 Thiamine biosynthesis 2
    Others/unknown 9
High copper (2 mmol/l CuSO4) Protein folding/chaperone 12 Transporters 7
  Antioxidants 6 Amino acid metabolism and transport 4
  Sulphur amino acid biosynthesis 6 Ribosomal proteins 2
  Carbohydrate metabolism 4 Others/unknown 11
  Stress response 4   
  Iron uptake 3   
  Signaling and transcription regulation 2   
  Lipid biosynthesis 2   
  Peptide biosynthesis 2   
  Other/unknown 28   
  1. BCS, bathocuproinedisulfonic acid; FZ, ferrozine.