Comparison of copper and iron metabolism between budding and fission yeast. The transcriptional responses of four clusters of S. cerevisiae genes identified by Van Bakel and coworkers  to changing copper levels are shown in comparison with expression changes in S. pombe homologs under similar conditions. Fission yeast genes with curated orthologs in budding yeast are indicated by asterisks. The clusters were supplemented with 10 additional genes that are known to be involved in S. cerevisiae copper and iron metabolism (+), as well as three genes found outside these clusters (other) . The maximal fold change in expression over time, as determined from averaged replicates at each time point, is displayed for each gene for the experimental conditions used (pCu-, low copper, 100 μmol/l bathocuproinedisulfonic acid [BCS]; pFe-, low iron, 100 μmol/l ferrozine; pCu+, high copper, 2 μmol/l CuSO4; cCu-, low copper, 100 μmol/l BCS; cCu+, high copper, 8 μmol/l CuSO4). The graded color scale at the bottom indicates the magnitude of expression changes.