Gene expression analysis of nuclear factor I-A deficient mice indicates delayed brain maturation

Table 3 Genes related to oligodendrocyte differentiation are differentially expressed in Nfia^-/- mice at P16

Gene name	Fold change of mRNA expression in Nfia^-/- versus Nfia^+/+ mice^a	Reference
Genes typically expressed in oligodendrocyte precursors or related to de-differentiation of precursor cells
Hmgb2	1.92	[45]
Sox2	1.28	[46]
Sox4	1.33/1.44	[47]
Sox11	1.88/2.22	[47]
Tenascin-C	1.47	[48]
Myef2^b	1.2	[39]
Genes typically expressed in mature oligodendrocytes or related to terminal oligodendrocyte differentiation
Mobp	-2.11/-2.10/-1.99/-1.98	[49]
Mal	-2.43	[50]
Mog	-1.95	[51]
Claudin 11	-1.67	[52]
Plp1	-1.58	[53]
Ugt8	-1.54/-1.45	[50]
Mag	-1.52	[53]
Dio2^c	-1.43	[38]
Car2	-1.35	[54]

^aAccording to microarray analysis; for genes represented by more than one probe set, the individual fold changes for each probe set are given. ^bIndirect link to oligodendrocyte maturation (My-EF2 can repress expression of myelin basic protein). ^cIndirect link to oligodendrocyte maturation (Dio2 catalyzes thyroxine to tri-iodothyronine conversion, and tri-iodothyronine triggers terminal differentiation of oligodendrocytes). P16, postnatal day 16.

ISSN: 1474-760X