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Table 3 Major biologic functions altered in aging versus young glp-1 adults

From: Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans

Biologic process/molecular functiona mRNA levels in aging versus young adult glp-1s Proportion changedb P valueb
Larval development Decreased 112/842 <0.0001
Ion transport Decreased 113/504 <0.0001
Generation of precursor metabolites and energy Decreased 78/474 <0.0001
Structural constituents of cuticle Decreased 88/144 <0.0001
Lipid metabolism Decreased 24/145 <0.0001
Oxidative phosphorylation Decreased 13/44 <0.0001
Aging (C elegans) Decreased 12/58 0.003
Catalytic activity Decreased 215/2734 0.0004
Glycolysis Decreased 4/15 0.014
Positive regulation of growth Increased 124/928 <0.0001
Cytoskeleton Increased 21/108 0.0003
Rab-related GTPase protein-mediated vesicular trafficking Increased 16/72 0.0003
Aging (C elegans) Increased 10/58 0.004
Osmoregulation Increased 21/137 0.007
Locomotion Increased 24/144 0.001
  1. Shown are major biologic functions altered in aging (6-day) as compared with young (1-day) glp-1 adults. aListed Gene Ontologies were identified as different in young and aging glp-1s in at least two of three different bioinformatic analyses. bProportion changed and p values are as determined by GOMiner. Complete Gene Ontology analyses are given in Additional data files 3, 4 (parts A and B), and 5. I changed the format slightly to avoid breaking up "glp-1s".