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Figure 1 | Genome Biology

Figure 1

From: Towards the uniform distribution of null P values on Affymetrix microarrays

Figure 1

Standard error as a function of the difference in means. Shown is σ2 as a function of x ¯ 1 x ¯ 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2Caerbhv2BYDwAHbqedmvETj2BSbqee0evGueE0jxyaibaiKI8=vI8tuQ8FMI8Gi=hEeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciGacaGaaeqabaqadeqadaaakeaaieaaceWF4bGbaebadaWgaaWcbaGaaGymaaqabaGccqGHsislceWF4bGbaebadaWgaaWcbaGaaGOmaaqabaaaaa@381E@ (see Equation 1 in the text) for probes from null genes from the comparison of Latin Square experiments 1 and 2 for (a) all approximately 500,000 probes on the array, (b) approximately 22,000 probes after RMA summation but in the absence of quantile-quantile normalization, and (c) after background correction, quantile-quantile normalization, and RMA summation. A small number of outlying data points are excluded from each panel. RMA, Robust Multichip Average.

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