Table 1 Overview of innate immunity components present or absent in selected Cnidaria
From: The innate immune repertoire in Cnidaria - ancestral complexity and stochastic gene loss
| Anthozoa | Hydrozoa | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Nematostella | Acropora | Hydra | |||||||
| Accession no. | e-value | Accession no. | e-value | Accession no. | e-value | ||||
| TLR pathway | |||||||||
| LBP | + | gnl|ti|1139929806 | 7e-51 | ND | + | gb|DT619160 | 2e-13 | ||
| CD14 | - | ND | - | ||||||
| TLR | + |
gnl|ti|573160901 gnl|ti|566578628 gnl|ti|558319530 gnl|ti|567085258 gnl|ti|581064934 | 1e-47 | + | gb|EF090256 | 2e-7 | - | ||
| MyD88 | + | gnl|ti|1139972660 | 4e-26 | ND | + | gb|CV182656 | 1e-18 | ||
| IRAK | + | gnl|ti|1146119691 | 3e-14 | ND | + | gb|DT608600 | 2e-10 | ||
| TRAF6 | + | gnl|ti|1135509399 | 2e-51 | + | gb|DY583189 | 1e-38 | + | gb|CV985667 | 3e-41 |
| TAK1 | + | gnl|ti|1135635219 | 1e-51 | + | gb|DY583694 | 8e-119 | + | gb|DN812953 | 1e-45 |
| IκK | + | gnl|ti|1135636054 | 5e-68 | ND | + | gb|CV985420 | 2e-60 | ||
| NF-κB | + | gnl|ti|1139960940 | 1e-74 | + | gb|DY582971 | 3e-36 | - | ||
| IFN pathway | |||||||||
| TRAM | + | gnl|ti|1139940977 | 9e-66 | + | gb|DY579224 | 5e-72 | + | gb|DT615400 | 1e-58 |
| TRIF | + | gnl|ti|1139933368 | 4e-07 | ND | ? | ||||
| TBK-1 | ? | ND | ? | ||||||
| IRF3 | + | gnl|ti|1146121907 | 6e-13 | ND | + | gb|DT609518 | 2e-14 | ||
| p65 | - | ND | - | ||||||
| IFN-β | - | ND | - | ||||||
| ECSIT pathway | |||||||||
| ECSIT | + | gnl|ti|1139978500 | 4e-35 | ND | + | gnl|ti|1223628732 | 2e-18 | ||
| MEKK1 | + | gnl|ti|1139956887 | 2e-28 | + | gb|DY581138 | 3e-83 | + | gnl|ti|1226566543 | 3e-25 |
| MKKs | + | gnl|ti|557758729 | 1e-14 | ND | + | gnl|ti|1121918104 | 1e-18 | ||
| JNK | + | gnl|ti|1135503269 | 1e-106 | ND | + | gnl|ti|877334588 | 2e-33 | ||
| p38 | + | gnl|ti|1139959014 | 1e-114 | + | gb|DY579712 | 5e-111 | + | gnl|ti|686048504 | 7e-39 |
| AP1 | + | gnl|ti|1139792930 | 3e-10 | + | gb|DY581320 | 3e-09 | + | gb|CX771032 | 7e-10 |
| ATF | + | gnl|ti|1139796564 | 4e-11 | ND | + | gb|CN624618 | 3e-06 | ||
| Other TLR related proteins | |||||||||
| HyTRR-1 | - | ND | + | gb|DQ449929 | 0 | ||||
| HyTRR-2 | - | ND | + | gb|DQ449930 | 0 | ||||
| IL1-R related proteins | |||||||||
| IL1R-1 | + | gnl|ti|573182253 | 0 | ND | - | ||||
| IL1R-2 | + | gnl|ti|557993643 | 0 | ND | - | ||||
| IL1R-3 | + | gnl|ti|567060226 | 0 | ND | - | ||||
| Complement system related proteins | |||||||||
| C3/A2M related | + |
gnl|ti|557724205 gnl|ti|559738307 gnl|ti|558391450 gnl|ti|573218050 gnl|ti|558266068 gnl|ti|573218146 gnl|ti|586367083 gnl|ti|557912603 gnl|ti|573084165 | 1e-84 | + | gb|EF090257 | 1e-134 | + |
gb|DT618439 gb|CN554187 gb|CO376061 | |
| C6/C7/C8 | - | ND | - | ||||||
| MAC/PF domain-containing proteins | |||||||||
| Apextrins | - | + | gb|EF091848 | 6e-15 | + | gb|CV185005 gb|DT613346 gb|CF655657 gb|DT620043 | 4e-04 | ||
| Tx60-A | + | gnl|ti|1139936806 gb|DY579588 | 7e-48 3e-35 | + | gb|DY579588 | 9e-48 | + | gb|CV464226 gb|CD680300 gb|BP512716 gb|CV464282 gb|DN246811 | 1e-07 |
| MPEG | + | gnl|ti|613559286 | 5e-59 | ND | - | ||||