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Table 1 Overview of innate immunity components present or absent in selected Cnidaria

From: The innate immune repertoire in Cnidaria - ancestral complexity and stochastic gene loss

 

Anthozoa

Hydrozoa

 

Nematostella

Acropora

Hydra

  

Accession no.

e-value

 

Accession no.

e-value

 

Accession no.

e-value

TLR pathway

         

   LBP

+

gnl|ti|1139929806

7e-51

ND

  

+

gb|DT619160

2e-13

   CD14

-

  

ND

  

-

  

   TLR

+

gnl|ti|573160901

gnl|ti|566578628

gnl|ti|558319530

gnl|ti|567085258

gnl|ti|581064934

1e-47

+

gb|EF090256

2e-7

-

  

   MyD88

+

gnl|ti|1139972660

4e-26

ND

  

+

gb|CV182656

1e-18

   IRAK

+

gnl|ti|1146119691

3e-14

ND

  

+

gb|DT608600

2e-10

   TRAF6

+

gnl|ti|1135509399

2e-51

+

gb|DY583189

1e-38

+

gb|CV985667

3e-41

   TAK1

+

gnl|ti|1135635219

1e-51

+

gb|DY583694

8e-119

+

gb|DN812953

1e-45

   IκK

+

gnl|ti|1135636054

5e-68

ND

  

+

gb|CV985420

2e-60

   NF-κB

+

gnl|ti|1139960940

1e-74

+

gb|DY582971

3e-36

-

  

IFN pathway

         

   TRAM

+

gnl|ti|1139940977

9e-66

+

gb|DY579224

5e-72

+

gb|DT615400

1e-58

   TRIF

+

gnl|ti|1139933368

4e-07

ND

  

?

  

   TBK-1

?

  

ND

  

?

  

   IRF3

+

gnl|ti|1146121907

6e-13

ND

  

+

gb|DT609518

2e-14

   p65

-

  

ND

  

-

  

   IFN-β

-

  

ND

  

-

  

ECSIT pathway

         

   ECSIT

+

gnl|ti|1139978500

4e-35

ND

  

+

gnl|ti|1223628732

2e-18

   MEKK1

+

gnl|ti|1139956887

2e-28

+

gb|DY581138

3e-83

+

gnl|ti|1226566543

3e-25

   MKKs

+

gnl|ti|557758729

1e-14

ND

  

+

gnl|ti|1121918104

1e-18

   JNK

+

gnl|ti|1135503269

1e-106

ND

  

+

gnl|ti|877334588

2e-33

   p38

+

gnl|ti|1139959014

1e-114

+

gb|DY579712

5e-111

+

gnl|ti|686048504

7e-39

   AP1

+

gnl|ti|1139792930

3e-10

+

gb|DY581320

3e-09

+

gb|CX771032

7e-10

   ATF

+

gnl|ti|1139796564

4e-11

ND

  

+

gb|CN624618

3e-06

Other TLR related proteins

         

   HyTRR-1

-

  

ND

  

+

gb|DQ449929

0

   HyTRR-2

-

  

ND

  

+

gb|DQ449930

0

IL1-R related proteins

         

   IL1R-1

+

gnl|ti|573182253

0

ND

  

-

  

   IL1R-2

+

gnl|ti|557993643

0

ND

  

-

  

   IL1R-3

+

gnl|ti|567060226

0

ND

  

-

  

Complement system related proteins

         

   C3/A2M related

+

gnl|ti|557724205

gnl|ti|559738307

gnl|ti|558391450

gnl|ti|573218050

gnl|ti|558266068

gnl|ti|573218146

gnl|ti|586367083

gnl|ti|557912603

gnl|ti|573084165

1e-84

+

gb|EF090257

1e-134

+

gb|DT618439

gb|CN554187

gb|CO376061

 

   C6/C7/C8

-

  

ND

  

-

  

MAC/PF domain-containing proteins

         

   Apextrins

-

  

+

gb|EF091848

6e-15

+

gb|CV185005 gb|DT613346 gb|CF655657 gb|DT620043

4e-04

   Tx60-A

+

gnl|ti|1139936806 gb|DY579588

7e-48 3e-35

+

gb|DY579588

9e-48

+

gb|CV464226 gb|CD680300 gb|BP512716 gb|CV464282 gb|DN246811

1e-07

   MPEG

+

gnl|ti|613559286

5e-59

ND

  

-

  
  1. Plus or minus indicate presence or absence of genes, respectively; components marked 'ND' could not be determined within the limited available Acropora dataset; question marks indicate not resolvable Blast results, mostly within kinase domain encoding sequences. All accession numbers originated either from GenBank (gb) or from NCBI trace archive (gnl|ti). The given e-values were obtained by BlastX searches against the NCBI nr protein database.