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Table 1 Overview of innate immunity components present or absent in selected Cnidaria

From: The innate immune repertoire in Cnidaria - ancestral complexity and stochastic gene loss

  Anthozoa Hydrozoa
  Nematostella Acropora Hydra
   Accession no. e-value   Accession no. e-value   Accession no. e-value
TLR pathway          
   LBP + gnl|ti|1139929806 7e-51 ND    + gb|DT619160 2e-13
   CD14 -    ND    -   
   TLR + gnl|ti|573160901
gnl|ti|566578628
gnl|ti|558319530
gnl|ti|567085258
gnl|ti|581064934
1e-47 + gb|EF090256 2e-7 -   
   MyD88 + gnl|ti|1139972660 4e-26 ND    + gb|CV182656 1e-18
   IRAK + gnl|ti|1146119691 3e-14 ND    + gb|DT608600 2e-10
   TRAF6 + gnl|ti|1135509399 2e-51 + gb|DY583189 1e-38 + gb|CV985667 3e-41
   TAK1 + gnl|ti|1135635219 1e-51 + gb|DY583694 8e-119 + gb|DN812953 1e-45
   IκK + gnl|ti|1135636054 5e-68 ND    + gb|CV985420 2e-60
   NF-κB + gnl|ti|1139960940 1e-74 + gb|DY582971 3e-36 -   
IFN pathway          
   TRAM + gnl|ti|1139940977 9e-66 + gb|DY579224 5e-72 + gb|DT615400 1e-58
   TRIF + gnl|ti|1139933368 4e-07 ND    ?   
   TBK-1 ?    ND    ?   
   IRF3 + gnl|ti|1146121907 6e-13 ND    + gb|DT609518 2e-14
   p65 -    ND    -   
   IFN-β -    ND    -   
ECSIT pathway          
   ECSIT + gnl|ti|1139978500 4e-35 ND    + gnl|ti|1223628732 2e-18
   MEKK1 + gnl|ti|1139956887 2e-28 + gb|DY581138 3e-83 + gnl|ti|1226566543 3e-25
   MKKs + gnl|ti|557758729 1e-14 ND    + gnl|ti|1121918104 1e-18
   JNK + gnl|ti|1135503269 1e-106 ND    + gnl|ti|877334588 2e-33
   p38 + gnl|ti|1139959014 1e-114 + gb|DY579712 5e-111 + gnl|ti|686048504 7e-39
   AP1 + gnl|ti|1139792930 3e-10 + gb|DY581320 3e-09 + gb|CX771032 7e-10
   ATF + gnl|ti|1139796564 4e-11 ND    + gb|CN624618 3e-06
Other TLR related proteins          
   HyTRR-1 -    ND    + gb|DQ449929 0
   HyTRR-2 -    ND    + gb|DQ449930 0
IL1-R related proteins          
   IL1R-1 + gnl|ti|573182253 0 ND    -   
   IL1R-2 + gnl|ti|557993643 0 ND    -   
   IL1R-3 + gnl|ti|567060226 0 ND    -   
Complement system related proteins          
   C3/A2M related + gnl|ti|557724205
gnl|ti|559738307
gnl|ti|558391450
gnl|ti|573218050
gnl|ti|558266068
gnl|ti|573218146
gnl|ti|586367083
gnl|ti|557912603
gnl|ti|573084165
1e-84 + gb|EF090257 1e-134 + gb|DT618439
gb|CN554187
gb|CO376061
 
   C6/C7/C8 -    ND    -   
MAC/PF domain-containing proteins          
   Apextrins -    + gb|EF091848 6e-15 + gb|CV185005 gb|DT613346 gb|CF655657 gb|DT620043 4e-04
   Tx60-A + gnl|ti|1139936806 gb|DY579588 7e-48 3e-35 + gb|DY579588 9e-48 + gb|CV464226 gb|CD680300 gb|BP512716 gb|CV464282 gb|DN246811 1e-07
   MPEG + gnl|ti|613559286 5e-59 ND    -   
  1. Plus or minus indicate presence or absence of genes, respectively; components marked 'ND' could not be determined within the limited available Acropora dataset; question marks indicate not resolvable Blast results, mostly within kinase domain encoding sequences. All accession numbers originated either from GenBank (gb) or from NCBI trace archive (gnl|ti). The given e-values were obtained by BlastX searches against the NCBI nr protein database.