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Table 1 Functional annotations enriched among transcripts that are upregulated in α-MHC positive cells

From: Global transcriptome analysis of murine embryonic stem cell-derived cardiomyocytes

Category

Term

Count

P value

GOTERM_MF_5

Hydrogen ion transporter activity

30

9.49 × e-17

GOTERM_MF_5

NADH dehydrogenase (quinone) activity

17

6.70 × e-14

GOTERM_MF_5

NADH dehydrogenase (ubiquinone) activity

17

6.70 × e-14

GOTERM_MF_5

Sodium ion transporter activity

17

6.70 × e-14

KEGG_PATHWAY

Oxidative phosphorylation (Mus musculus)

25

8.59 × e-12

GOTERM_CC_5

Myofibril

16

1.36 × e-10

GOTERM_CC_5

Mitochondrion

61

7.52 × e-09

GOTERM_CC_5

Striated muscle thin filament

8

4.12 × e-07

GOTERM_BP_5

Cation transport

30

7.59 × e-06

GOTERM_CC_5

Mitochondrial membrane

21

2.91 × e-05

GOTERM_CC_5

Mitochondrial inner membrane

18

1.21 × e-04

GOTERM_MF_5

Voltage-gated ion channel activity

14

1.75 × e-04

GOTERM_BP_5

Coenzyme metabolism

13

2.59 × e-04

GOTERM_BP_5

Ion transport

35

3.21 × e-04

GOTERM_CC_5

Mitochondrial electron transport chain

10

3.40 × e-04

GOTERM_BP_5

Cytoskeleton organization and biogenesis

24

5.84 × e-04

GOTERM_CC_5

Actin cytoskeleton

19

5.85 × e-04

GOTERM_BP_5

Electron transport

23

1.41 × e-03

GOTERM_CC_5

Cytoskeleton

44

1.46 × e-03

GOTERM_MF_5

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

9

1.70 × e-03

GOTERM_CC_5

Sodium

4

2.39 × e-03

KEGG_PATHWAY

Calcium signaling pathway (Mus musculus)

17

2.42 × e-03

GOTERM_BP_5

Proton transport

7

2.92 × e-03

GOTERM_MF_5

Sodium

4

5.26 × e-03

GOTERM_BP_5

Phosphate metabolism

33

7.20 × e-03

GOTERM_BP_5

Oxidative phosphorylation

7

7.63 × e-03

GOTERM_BP_5

Vesicle-mediated transport

16

7.96 × e-03

GOTERM_BP_5

Hydrogen transport

7

8.19 × e-03

GOTERM_MF_5

Cytochrome c oxidase activity

5

9.38 × e-03

GOTERM_MF_5

ATPase activity, coupled to transmembrane movement of substances

10

1.24 × e-02

GOTERM_BP_5

Negative regulation of signal transduction

5

1.55 × e-02

GOTERM_BP_5

Negative regulation of cell organization and biogenesis

4

1.56 × e-02

GOTERM_BP_5

Co-factor biosynthesis

8

1.62 × e-02

GOTERM_CC_5

Myosin

7

1.75 × e-02

GOTERM_BP_5

Cell growth

7

2.03 × e-02

GOTERM_BP_5

Regulation of cell size

7

2.36 × e-02

GOTERM_BP_5

Negative regulation of Wnt receptor signaling pathway

3

2.55 × e-02

GOTERM_MF_5

Calcium

3

2.69 × e-02

GOTERM_BP_5

Enzyme-linked receptor protein signaling pathway

11

3.03 × e-02

GOTERM_BP_5

Nucleotide biosynthesis

8

3.53 × e-02

GOTERM_MF_5

Protein kinase activity

25

3.66 × e-02

GOTERM_BP_5

Cellular protein metabolism

89

3.88 × e-02

GOTERM_BP_5

Negative regulation of nucleobase, nucleoside, nucleotide, and nucleic acid metabolism

9

4.10 × e-02

GOTERM_BP_5

Fatty acid metabolism

8

4.71 × e-02

GOTERM_BP_5

Intracellular receptor-mediated signaling pathway

3

5.47 × e-02

GOTERM_MF_5

Protein phosphatase inhibitor activity

3

5.77 × e-02

GOTERM_BP_5

Regulation of Wnt receptor signaling pathway

3

6.15 × e-02

GOTERM_BP_5

Response to temperature

4

6.33 × e-02

GOTERM_BP_5

Gas transport

3

6.86 × e-02

GOTERM_BP_5

Oxygen transport

3

6.86 × e-02

BIOCARTA

P38 MAPK signaling pathway (Mus musculus)

5

7.68 × e-02

GOTERM_MF_5

Arsenate reductase (glutaredoxin) activity

2

7.68 × e-02

GOTERM_MF_5

Hydrogen-exporting ATPase activity, phosphorylative mechanism

4

7.72 × e-02

GOTERM_MF_5

Microtubule binding

4

7.72 × e-02

GOTERM_BP_5

Apoptosis

17

7.90 × e-02

GOTERM_MF_5

Transcription coactivator activity

5

8.72 × e-02

GOTERM_BP_5

Endocytosis

8

8.94 × e-02

GOTERM_BP_5

Nucleotide metabolism

9

9.01 × e-02

GOTERM_BP_5

Secretory pathway

7

9.20 × e-02

GOTERM_BP_5

Cellular lipid metabolism

15

9.71 × e-02

GOTERM_MF_5

Transcription corepressor activity

4

9.75 × e-02

GOTERM_CC_5

Adherens junction

5

9.84 × e-02

GOTERM_BP_5

Second messenger mediated signaling

6

9.87 × e-02

  1. Functional annotations that are enriched among transcripts upregulated in α-myosin heavy chain (MHC) positive cells (intersection of upregulation in the 15-day-old α-MHC+ cardiomyocytes [twofold, Student's t-test P value < 0.01] as compared with the control cells in the 15-day-old embryoid bodies and compared with the undifferentiated α-MHC embryonic stem cells). 'Count' refers to the number of transcripts in the respective category; the 'P value' column shows the value of Fisher's exact t-test, as used by DAVID to measure the enrichment in annotation terms. GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinase.