Table 3 Neural crest associated Pfam domains emerging in vertebrates

Slc12a6

Solute carrier family 12, member 6

pro

AA_permease

-

-

-

-

KCl_Cotrans_1

-

Apc

Adenomatosis polyposis coli

pro

-

Arm

APC_crr APC_15aa

-

-

EB1_binding APC_basic SAMP

-

Asph

Aspartate-beta-hydroxylase

pro

Asp_Arg_Hydrox

-

-

-

-

Asp-B-Hydro_N

-

Top2b

Topoisomerase (DNA) II beta

pro

DNA_topoisoIV DNA_gyraseB HATPase_c

-

-

-

-

DTHCT

-

Nef3

Neurofilament 3, medium

pro

-

-

Filament

-

-

Filament_head

-

Nefl

Neurofilament, light polypeptide

pro

-

-

Filament

-

-

Filament_head

-

Cryab

Crystallin, alpha B

pro

HSP20

-

-

-

-

Crystallin

-

Rabggta

Rab geranylgeranyl transferase, a subunit

pro

LRR_1

LRR_2 PPTA

-

-

-

RabGGT_insert

-

Otx1

Orthodenticle homolog 1

euk

-

Homeobox

-

-

-

TF_Otx

-

Otx2

Orthodenticle homolog 2

euk

-

Homeobox

-

-

-

TF_Otx

-

Zfp98

Zinc finger protein 98

euk

zf-C2H2

-

-

-

-

SCAN

-

Prph1

Peripherin 1

met

-

-

Filament

-

-

Filament_head

-

Gfra1

Glial cell line derived neurotrophic factor family receptor alpha 1

met

-

-

-

-

-

GDNF

-

Cdx1

Caudal type homeo box 1

met

-

Homeobox

-

-

-

Caudal_act

-

Cdx2

Caudal type homeo box 2

met

-

Homeobox

-

-

-

Caudal_act

-

Hoxb9

Homeo box B9

met

-

Homeobox

-

-

-

Hox9_act

-

Hoxa9

Homeo box A9

met

-

Homeobox

-

-

-

Hox9_act

-

Nr3c1

Nuclear receptor subfamily 3, group C, member 1

met

-

-

Hormone_recep zf-C4

-

-

GCR

-

Pdgfa

Platelet derived growth factor, alpha

met

-

-

PDGF

-

-

PDGF_N

-

Bdnf

Brain derived neurotrophic factor

deu

-

-

-

-

-

NGF

-

Ntf3

Neurotropin 3

deu

-

-

-

-

-

NGF

-

P2rx7

Purinergic receptor P2X, ligand-gated ion channel, 7

deu

-

-

-

-

-

P2X_receptor

-

Hapln1

Hyaluronan and proteoglycan link protein 1

cor

-

-

V-set

-

-

Xlink

-

Nppc

Natriuretic peptide precursor type C

ver

-

-

-

-

-

ANP

-

Calca

Calcitonin/calcitonin-related polypeptide, alpha

ver

-

-

-

-

-

Calc_CGRP_IAPP

-

Iapp

Islet amyloid polypeptide

ver

-

-

-

-

-

Calc_CGRP_IAPP

-

Cart

Cocaine and amphetamine regulated transcript

ver

-

-

-

-

-

CART

-

Edn1

Endothelin 1

ver

-

-

-

-

-

Endothelin

-

Edn3

Endothelin 3

ver

-

-

-

-

-

Endothelin

-

Nrg1

Neuregulin 1

ver

I-set

EGF

ig V-set

-

-

Neuregulin

-

Pomc1

Pro-opiomelanocortin-alpha

ver

-

-

-

-

-

Op_neuropeptide ACTH_domain

-

Pthlh

Parathyroid hormone-like peptide

ver

-

-

-

-

-

Parathyroid

-

Pth

Parathyroid hormone

ver

-

-

-

-

-

Parathyroid

-

Pde6g

Phosphodiesterase 6G, cGMP-specific, rod, gamma

ver

-

-

-

-

-

PDE6_gamma

-

a

Nonagouti

mam

-

-

-

-

-

Agouti

-

Osm

Oncostatin M

mam

-

-

-

-

-

LIF_OSM

-

Kitl

Kit ligand

mam

-

-

-

-

-

SCF

-