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Table 3 Neural crest associated Pfam domains emerging in vertebrates

From: New genes in the evolution of the neural crest differentiation program

    Group
Symbol Gene blast pro euk met deu chr ver mam
Slc12a6 Solute carrier family 12, member 6 pro AA_permease - - - - KCl_Cotrans_1 -
Apc Adenomatosis polyposis coli pro - Arm APC_crr APC_15aa - - EB1_binding APC_basic SAMP -
Asph Aspartate-beta-hydroxylase pro Asp_Arg_Hydrox - - - - Asp-B-Hydro_N -
Top2b Topoisomerase (DNA) II beta pro DNA_topoisoIV DNA_gyraseB HATPase_c - - - - DTHCT -
Nef3 Neurofilament 3, medium pro - - Filament - - Filament_head -
Nefl Neurofilament, light polypeptide pro - - Filament - - Filament_head -
Cryab Crystallin, alpha B pro HSP20 - - - - Crystallin -
Rabggta Rab geranylgeranyl transferase, a subunit pro LRR_1 LRR_2 PPTA - - - RabGGT_insert -
Otx1 Orthodenticle homolog 1 euk - Homeobox - - - TF_Otx -
Otx2 Orthodenticle homolog 2 euk - Homeobox - - - TF_Otx -
Zfp98 Zinc finger protein 98 euk zf-C2H2 - - - - SCAN -
Prph1 Peripherin 1 met - - Filament - - Filament_head -
Gfra1 Glial cell line derived neurotrophic factor family receptor alpha 1 met - - - - - GDNF -
Cdx1 Caudal type homeo box 1 met - Homeobox - - - Caudal_act -
Cdx2 Caudal type homeo box 2 met - Homeobox - - - Caudal_act -
Hoxb9 Homeo box B9 met - Homeobox - - - Hox9_act -
Hoxa9 Homeo box A9 met - Homeobox - - - Hox9_act -
Nr3c1 Nuclear receptor subfamily 3, group C, member 1 met - - Hormone_recep zf-C4 - - GCR -
Pdgfa Platelet derived growth factor, alpha met - - PDGF - - PDGF_N -
Bdnf Brain derived neurotrophic factor deu - - - - - NGF -
Ntf3 Neurotropin 3 deu - - - - - NGF -
P2rx7 Purinergic receptor P2X, ligand-gated ion channel, 7 deu - - - - - P2X_receptor -
Hapln1 Hyaluronan and proteoglycan link protein 1 cor - - V-set - - Xlink -
Nppc Natriuretic peptide precursor type C ver - - - - - ANP -
Calca Calcitonin/calcitonin-related polypeptide, alpha ver - - - - - Calc_CGRP_IAPP -
Iapp Islet amyloid polypeptide ver - - - - - Calc_CGRP_IAPP -
Cart Cocaine and amphetamine regulated transcript ver - - - - - CART -
Edn1 Endothelin 1 ver - - - - - Endothelin -
Edn3 Endothelin 3 ver - - - - - Endothelin -
Nrg1 Neuregulin 1 ver I-set EGF ig V-set - - Neuregulin -
Pomc1 Pro-opiomelanocortin-alpha ver - - - - - Op_neuropeptide ACTH_domain -
Pthlh Parathyroid hormone-like peptide ver - - - - - Parathyroid -
Pth Parathyroid hormone ver - - - - - Parathyroid -
Pde6g Phosphodiesterase 6G, cGMP-specific, rod, gamma ver - - - - - PDE6_gamma -
a Nonagouti mam - - - - - Agouti -
Osm Oncostatin M mam - - - - - LIF_OSM -
Kitl Kit ligand mam - - - - - SCF -
  1. The table summarizes a list of those neural crest genes having at least one Pfam domain appearing first in vertebrates. All the corresponding Pfam domains of these genes, when these domains have appeared, and the classification of the genes according to our previous sequential blast analysis (blast) are indicated. cor, chordata; deu, deuterostomia; euk, eukaryota; mam, mammalia; met, metazoa; pro, prokaryota; ver, vertebrata.