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Table 2 Neural crest genes compiled using Phenotype Ontology annotations (phenotypic information derived from mutant mice studies)

From: New genes in the evolution of the neural crest differentiation program

Group Gene
Deuterostomia Brain derived neurotrophic factor
  Fanconi anemia, complementation group A
  Fos-like antigen 2
  Neurotropin 3
  Purinergic receptor P2X, ligand-gated ion channel, 7
  Rod outer segment membrane protein 1
Vertebrata BCL2-like 11 (apoptosis facilitator)
  Calcitonin/calcitonin-related polypeptide, alpha
  Cocaine and amphetamine regulated transcript
  Endothelin 1
  Endothelin 3
  Formin 1
  Glial cell line derived neurotrophic factor
  Gonadotropin releasing hormone 1
  Hermansky-Pudlak syndrome 6
  Integrin, alpha 10
  Islet amyloid polypeptide
  Leukocyte cell derived chemotaxin 1
  Matrix Gla protein
  Melanoma inhibitory activity 1
  Myelin protein zero
  Natriuretic peptide precursor type C
  Neuregulin 1
  Parathyroid hormone
  Parathyroid hormone-like peptide
  Phosphodiesterase 6G, cGMP-specific, rod, gamma
  Treacher Collins Franceschetti syndrome 1, homolog
Chordata Activating transcription factor 4
  Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
  Claudin 14
  Epilepsy, progressive myoclonic epilepsy, type 2 gene alpha
  Fos-like antigen 1
  Gap junction membrane channel protein beta 6
  Hyaluronan and proteoglycan link protein 1
  Transforming growth factor, beta receptor III
Mammalia Adrenocortical dysplasia
  Amelogenin X chromosome
  BH3 interacting domain death agonist
  Colony stimulating factor 2 (granulocyte-macrophage)
  Harakiri, BCL2 interacting protein (contains only BH3 domain)
  Kit ligand
  Matrix extracellular phosphoglycoprotein with ASARM motif (bone)
  MyoD family inhibitor
  Oncostatin M
  Programmed cell death 1
  TYRO protein tyrosine kinase binding protein
  1. The first appearance of neural crest genes was then determined using the sequential blast pipeline (Figure 1). The table contains the complete name of neural crest genes emerging in deuterostomia, chordata, vertebrata and mammalia.