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Table 2 Neural crest genes compiled using Phenotype Ontology annotations (phenotypic information derived from mutant mice studies)

From: New genes in the evolution of the neural crest differentiation program

Group

Gene

Deuterostomia

Brain derived neurotrophic factor

 

Fanconi anemia, complementation group A

 

Fos-like antigen 2

 

Neurotropin 3

 

Noggin

 

Purinergic receptor P2X, ligand-gated ion channel, 7

 

Rod outer segment membrane protein 1

Vertebrata

BCL2-like 11 (apoptosis facilitator)

 

Calcitonin/calcitonin-related polypeptide, alpha

 

Cocaine and amphetamine regulated transcript

 

Endothelin 1

 

Endothelin 3

 

Formin 1

 

Glial cell line derived neurotrophic factor

 

Gonadotropin releasing hormone 1

 

Hermansky-Pudlak syndrome 6

 

Integrin, alpha 10

 

Islet amyloid polypeptide

 

Leukocyte cell derived chemotaxin 1

 

Matrix Gla protein

 

Melanoma inhibitory activity 1

 

Myelin protein zero

 

Natriuretic peptide precursor type C

 

Neuregulin 1

 

Neurturin

 

Parathyroid hormone

 

Parathyroid hormone-like peptide

 

Phosphodiesterase 6G, cGMP-specific, rod, gamma

 

Pro-opiomelanocortin-alpha

 

Silver

 

Tenomodulin

 

Treacher Collins Franceschetti syndrome 1, homolog

Chordata

Activating transcription factor 4

 

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

 

Claudin 14

 

Epilepsy, progressive myoclonic epilepsy, type 2 gene alpha

 

Fos-like antigen 1

 

Gap junction membrane channel protein beta 6

 

Hyaluronan and proteoglycan link protein 1

 

Transforming growth factor, beta receptor III

Mammalia

Adrenocortical dysplasia

 

Ameloblastin

 

Amelogenin X chromosome

 

BH3 interacting domain death agonist

 

Colony stimulating factor 2 (granulocyte-macrophage)

 

Harakiri, BCL2 interacting protein (contains only BH3 domain)

 

Kit ligand

 

Leptin

 

Matrix extracellular phosphoglycoprotein with ASARM motif (bone)

 

MyoD family inhibitor

 

Nonagouti

 

Oncostatin M

 

Programmed cell death 1

 

TYRO protein tyrosine kinase binding protein

  1. The first appearance of neural crest genes was then determined using the sequential blast pipeline (Figure 1). The table contains the complete name of neural crest genes emerging in deuterostomia, chordata, vertebrata and mammalia.