Developmental stage related patterns of codon usage and genomic GC content: searching for evolutionary fingerprints with models of stem cell differentiation

Table 1 Descriptions and definitions of each cell type in the models of stem cell differentiation

Abbreviation	Model	Descriptions	Definitions
ESC	A	Pluripotent stem cell	C57Bl/6 cell line
NSC	A	Adult neural stem cell	*Neurosphere
LVB	A	Adult mature neural cell	Lateral ventricles of the brain
HSC	A	Long-term hematopoietic stem cell	^†Lin^- c-Kit⁺ Sca-1⁺ CD34^- Hoe^low
BM	A	Non-hematopoietic stem cell	Bone marrow main population
ESC	B	Pluripotent stem cell	CCE cell line
FNSC	B	Fetal neural stem cell	*^†Hoe^low from neurosphere
FLHSC	B	Fetal liver hematopoietic stem cell	^†Lin^- AA4.1⁺ c-Kit⁺ Sca-1⁺
FLLCP	B	Fetal liver hematopoietic progenitor cell	^†Lin^- AA4.1⁺ c-Kit⁺ Sca-1^-
FLMBC	B	Fetal liver mature blood cell	^†Lin⁺
LTHSC	B	Long-term hematopoietic stem cell	^†Lin^- c-Kit⁺ Sca-1⁺Rho^low
STHSC	B	Short-term hematopoietic stem cell	^†Lin^-c-Kit⁺ Sca-1⁺Rho^high
LCP	B	Hematopoietic progenitor cell	^†Lin^-c-Kit⁺ Sca-1^-
MBC	B	Mature blood cell	^†Lin⁺
CD45	B	Contain long-term hematopoietic stem cells	^†CD45⁺ c-Kit⁺ Sca-1⁺

Stem cells and progenitor cells are defined in terms of their surface markers (^†by FACS sorting) and/or growth characters (*by selective culture). ESCs in both models A and B were functionally tested. For detailed descriptions and related references, see [54,55].

ISSN: 1474-760X