Figure 6

Sequence and structure alignments of 3D-BLAST search results using yCCS as the query. This protein consists of the amino-terminal and carboxyl-terminal domains. Sequence alignments (structural alphabet and amino acid sequences) of (a) amino-terminal domain and (b) carboxyl-terminal domain between the query protein and homologous proteins (Protein Data Bank [PDB] codes 1CC8-A and 1QOE-A, respectively). Structure alignments of (c) amino-terminal domain and (d) carboxyl-terminal domain between the query protein and the homologous proteins (PDB codes 1CC8-A and 1QOE-A, respectively). The aligned secondary structures are denoted as a continuous color spectrum from red through orange, yellow, green, and blue to violet. The amino-terminal domain contains an MT/HCXXC metal binding motif (blue box in panel a and wireframe model in panel c). yCCS, yeast copper chaperone for superoxide dismutase.