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Table 1 Orthologous genes associated with CNEs (and uc-elements) in humans, flies and worms

From: Parallel evolution of conserved non-coding elements that target a common set of developmental regulatory genes from worms to humans

 

C. elegans

D. melanogaster

H. sapiens

Cluster number

Gene name

Number of associated wCNEs

Gene symbol

Number of associated uc-elements

Gene name

Number of associated hCNEs

1

ZC123.3

4

zfh2

2

ATBF1

3

     

ZFHX4

10

2

ceh-31

3

B-H1

40

BARHL2

18

 

ceh-30

2

B-H2

39

  

3

ceh-44

1

ct

38

CUTL2

2

4

unc-3

5

kn

1

EBF3

15

5

C18B12.3

1

al

17

ENSG00000165606

5

6

egl-43

1

CG31753

9

EVI1

2

     

PRDM16

1

7

lin-39

1

Scr

21

HOXA5

2

     

HOXB5

2

     

HOXC5

2

8

irx-1

1

caup

12

IRX4

8

   

mirr

23

IRX6

3

   

ara

5

  

9

mab-21

2

CG4766

6

MAB21L1

5

   

mab-2

9

MAB21L2

4

10

cog-1

3

HGTX

20

NKX6-1

7

11

nhr-67

1

dsf

3

NR2E1

1

12

nhr-6

2

Hr38

8

NR4A2

12

13

vab-3

10

toy

1

PAX6

2

14

unc-30

1

ptx1

11

PITX2

3

15

unc-86

2

acj6

6

POU4F1

1

     

POU4F2

1

16

ptc-1

1

ptc

4

PTCH

3

17

egl-27

3

gug

7

RERE

1

18

unc-10

1

Rim

3

RIMS2

1

19

rnt-1

3

run

13

RUNX3

1

20

sem-4

4

Salm

32

SALL1

5

     

SALL3

11

     

SALL4

1

21

sox-3

2

SoxN

13

SOX1

2

     

SOX2

2

22

tbx-2

4

bi

28

TBX2

1

23

K06A1.1

1

AP-2

5

TFAP2A

2

     

TFAP2D

2

24

zag-1

4

zfh1

7

ZFHX1B

18

25

ref-2

1

opa

11

ZIC1

1

     

ZIC2

1

     

ZIC4

4

26

tlp-1

1

elB

9

ZNF503

3

   

noc

35

ZNF703

4

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Genome Biology

ISSN: 1474-760X

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