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Table 3 Comparison of predicted protein complexes with known MIPS complexes

From: Consistent dissection of the protein interaction network by combining global and local metrics

 

BCD

GN

ECC

MCL

Unfiltered

    

   100%*

59 (6.9†)

27 (4.4)

56 (6.4)

53 (7.5)

   >50%

65 (7.6)

51 (8.3)

56 (6.4)

63 (9.0)

   >0%

125 (14.7)

92 (15.0)

122 (13.9)

153 (21.8)

   No overlap

601 (70.7)

444 (72.3)

641 (73.3)

434 (61.7)

   Accuracy‡

0.70

0.64

0.62

0.65

   Separation‡

0.21

0.16

0.20

0.27

Filtered

    

   100%

53 (13.6)

45 (15.2)

50 (10.2)

67 (28.9)

   >50%

46 (11.8)

38 (12.8)

49 (10.0)

24 (10.3)

   >0%

83 (21.2)

66 (22.2)

120 (24.4)

50 (21.6)

   No overlap

209 (53.5)

148 (49.8)

272 (55.4)

91 (39.2)

   Accuracy

0.73

0.71

0.61

0.67

   Separation

0.29

0.28

0.26

0.38

  1. *The overlap is defined as the percentage of proteins in the best-matching MIPS complexes in a predicted cluster. Complexes with only one protein are excluded in this analysis. †The percentage of total predicted protein complexes. ‡The geometric accuracy and separation according to [16].
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Genome Biology

ISSN: 1474-760X

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